Think Forward.

AI+Health: An Undelivered Promise 3561

AI is everywhere, or so would it seems, but the promises made for Drug Discovery and Medicine are still yet to be fulfilled. AI seems to always spring from a Promethean impulse. The goal of creating a life beyond life, doing the work of gods by creating a new life form as Prometheus created humanity. From Techne to independent life, a life that looks life us. Something most people refer to as AGI today. This is the biggest blind spot of AI development. The big successes of AI are in a certain way always in the same domains: - Image Processing - Natural Language Processing The reason is simple, we are above all visual, talking animals. Our Umwelt, the world we inhabit is mostly a world of images and language, every human is an expert in these two fields. Interestingly, most humans are not as sound aware as they are visually aware. Very few people can separate the different tracks in a music piece, let alone identify certain frequencies or hear delicate compressions and distortions. We are not so good with sound, and it shows in the relatively less ground breaking AI tools available for sound processing. The same phenomenon explains why AI struggles to achieve in very complex domains such as Biology and Chemistry. At it's core, modern AI is nothing more than a powerful general way to automatically guess relevant mathematical functions describing a phenomenon from collected data. What statisticians call a *Model*. From this great power derives the domain chief illusion: because the tool is general, therefore the wielder of that tool can apply it to any domain. Experience shows that this thinking is flawed. Every AI model is framed between two thing: its dataset (input) and its desired output as represented by the loss function. What is important, what is good, what is bad, how should the dataset be curated, how should the model be adjusted. For all these questions and more, you need a deep knowledge of the domain, of the assumptions of the domain, of the technicalities of the domain, of the limitations that are inherent to data collection in that domain. Domain knowledge is paramount, because AI algorithms are always guided by the researchers and engineers. This I know from experience, having spent about 17 years closely working with biologists. Pairing AI specialists with domain specialist with little knowledge of AI also rarely delivers. A strategy that has been tested time and time again in the last 10 years. Communication is hard and slow, most is lost in translation. The best solution is to have AI experts that are also experts in the applied domain, or domain experts that are also AI experts. Therefore the current discrepancies we see in AI performances across domains, could be layed at the feet of universities, and there siloed structures. Universities are organized in independent departments that teach independently. AI is taught at the Computer Science department, biology at the Biochemistry department. These two rarely meet in any substantial manner. It was true went I was a student, it is still true today. This is one of the things we are changing at the Faculty of Medical Science of the University Mohammed VI Polytechnic. Students in Medicine and Pharmacy have to go through a serious AI and Data science class over a few years. They learn to code, they learn the mathematical concepts of AI, they learn to gather their own datasets, to derive their hypothesizes, and build, train and evaluate their own models using pyTorch. The goal being to produce a new generation of scientists that are intimate with their domain as well as with modern AI. One that can consistently deliver the promises of AI for Medicine and Drug Discovery.
Tariq Daouda

Tariq Daouda

CEO, co-founder & Head Software Architect of Bluwr. Professor at the Faculty of Medical Sciences of the University Mohammed VI Polytechnic, I specialize in AI for Biomedical applications.


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THE ENCHIRIDION - I 2333

There are things which are within our power, and there are things which are beyond our power. Within our power are opinion, aim, desire, aversion, and, in one word, whatever affairs are our own. Beyond our power are body, property, reputation, office, and, in one word, whatever are not properly our own affairs. Now the things within our power are by nature free, unrestricted, unhindered; but those beyond our power are weak, dependent, restricted, alien. Remember, then, that if you attribute freedom to things by nature dependent and take what belongs to others for your own, you will be hindered, you will lament, you will be disturbed, you will find fault both with gods and men. But if you take for your own only that which is your own and view what belongs to others just as it really is, then no one will ever compel you, no one will restrict you; you will find fault with no one, you will accuse no one, you will do nothing against your will; no one will hurt you, you will not have an enemy, nor will you suffer any harm. Aiming, therefore, at such great things, remember that you must not allow yourself any inclination, however slight, toward the attainment of the others; but that you must entirely quit some of them, and for the present postpone the rest. But if you would have these, and possess power and wealth likewise, you may miss the latter in seeking the former; and you will certainly fail of that by which alone happiness and freedom are procured. Seek at once, therefore, to be able to say to every unpleasing semblance, “You are but a semblance and by no means the real thing.” And then examine it by those rules which you have; and first and chiefly by this: whether it concerns the things which are within our own power or those which are not; and if it concerns anything beyond our power, be prepared to say that it is nothing to you.

THE ADVENTURES OF TOM SAWYER - PREFACE 2433

Most of the adventures recorded in this book really occurred; one or two were experiences of my own, the rest those of boys who were schoolmates of mine. Huck Finn is drawn from life; Tom Sawyer also, but not from an individual—he is a combination of the characteristics of three boys whom I knew, and therefore belongs to the composite order of architecture. The odd superstitions touched upon were all prevalent among children and slaves in the West at the period of this story—that is to say, thirty or forty years ago. Although my book is intended mainly for the entertainment of boys and girls, I hope it will not be shunned by men and women on that account, for part of my plan has been to try to pleasantly remind adults of what they once were themselves, and of how they felt and thought and talked, and what queer enterprises they sometimes engaged in. THE AUTHOR. HARTFORD, 1876.

THE MEDITATIONS - Book I.[1/3] 2501

1. I learned from my grandfather, Verus, to use good manners, and to put restraint on anger. 2. In the famous memory of my father I had a pattern of modesty and manliness. 3. Of my mother I learned to be pious and generous; to keep myself not only from evil deeds, but even from evil thoughts; and to live with a simplicity which is far from customary among the rich. 4. I owe it to my great-grandfather that I did not attend public lectures and discussions, but had good and able teachers at home; and I owe him also the knowledge that for things of this nature a man should count no expense too great. 5. My tutor taught me not to favour either green or blue at the chariot races, nor, in the contests of gladiators, to be a supporter either of light or heavy armed. He taught me also to endure labour; not to need many things; to serve myself without troubling others; not to intermeddle in the affairs of others, and not easily to listen to slanders against them. 6. Of Diognetus I had the lesson not to busy myself about vain things; not to credit the great professions of such as pretend to work wonders, or of sorcerers about their charms, and their expelling of Demons and the like; not to keep quails (for fighting or divination), nor to run after such things; to suffer freedom of speech in others, and to apply myself heartily to philosophy. Him also I must thank for my hearing first Bacchius, then Tandasis and Marcianus; that I wrote dialogues in my youth, and took a liking to the philosopher’s pallet and skins, and to the other things which, by the Grecian discipline, belong to that profession. 7. To Rusticus I owe my first apprehensions that my nature needed reform and cure; and that I did not fall into the ambition of the common Sophists, either by composing speculative writings or by declaiming harangues of exhortation in public; further, that I never strove to be admired by ostentation of great patience in an ascetic life, or by display of activity and application; that I gave over the study of rhetoric, poetry, and the graces of language; and that I did not pace my house in my senatorial robes, or practise any similar affectation. I observed also the simplicity of style in his letters, particularly in that which he wrote to my mother from Sinuessa. I learned from him to be easily appeased, and to be readily reconciled with those who had displeased me or given cause of offence, so soon as they inclined to make their peace; to read with care; not to rest satisfied with a slight and superficial knowledge; nor quickly to assent to great talkers. I have him to thank that I met with the discourses of Epictetus, which he furnished me from his own library. 8. From Apollonius I learned true liberty, and tenacity of purpose; to regard nothing else, even in the smallest degree, but reason always; and always to remain unaltered in the agonies of pain, in the losses of children, or in long diseases. He afforded me a living example of how the same man can, upon occasion, be most yielding and most inflexible. He was patient in exposition; and, as might well be seen, esteemed his fine skill and ability in teaching others the principles of philosophy as the least of his endowments. It was from him that I learned how to receive from friends what are thought favours without seeming humbled by the giver or insensible to the gift. 9. Sextus was my pattern of a benign temper, and his family the model of a household governed by true paternal affection, and a steadfast purpose of living according to nature. Here I could learn to be grave without affectation, to observe sagaciously the several dispositions and inclinations of my friends, to tolerate the ignorant and those who follow current opinions without examination. His conversation showed how a man may accommodate himself to all men and to all companies; for though companionship with him was sweeter and more pleasing than any sort of flattery, yet he was at the same time highly respected and reverenced. No man was ever more happy than he in comprehending, finding out, and arranging in exact order the great maxims necessary for the conduct of life. His example taught me to suppress even the least appearance of anger or any other passion; but still, with all this perfect tranquillity, to possess the tenderest and most affectionate heart; to be apt to approve others yet without noise; to have much learning and little ostentation. 10. I learned from Alexander the Grammarian to avoid censuring others, to refrain from flouting them for a barbarism, solecism, or any false pronunciation. Rather was I dexterously to pronounce the words rightly in my answer, confining approval or objection to the matter itself, and avoiding discussion of the expression, or to use some other form of courteous suggestion. 11. Fronto made me sensible how much of envy, deceit and hypocrisy surrounds princes; and that generally those whom we account nobly born have somehow less natural affection. 12. I learned from Alexander the Platonist not often nor without great necessity to say, or write to any man in a letter, that I am not at leisure; nor thus, under pretext of urgent affairs, to make a practice of excusing myself from the duties which, according to our various ties, we owe to those with whom we live. 13. Of Catulus I learned not to condemn any friend’s expostulation even though it were unjust, but to try to recall him to his former disposition; to stint no praise in speaking of my masters, as is recounted of Domitius and Athenodorus; and to love my children with true affection. 14. Of Severus, my brother, I learned to love my kinsmen, to love truth, to love justice. Through him I came to know Thrasea, Helvidius, Cato, Dion, and Brutus. He gave me my first conception of a Commonwealth founded upon equitable laws and administered with equality of right; and of a Monarchy whose chief concern is the freedom of its subjects. Of him I learned likewise a constant and harmonious devotion to Philosophy; to be ready to do good, to be generous with all my heart. He taught me to be of good hope and trustful of the affection of my friends. I observed in him candour in declaring what he condemned in the conduct of others; and so frank and open was his behaviour, that his friends might easily see without the trouble of conjecture what he liked or disliked.