Think Forward.

Le syndrome de Rett une maladie neurologique lourde 2607

Dr Moussayer khadija, 2 y.
- Health -
2.5 min read.
Le syndrome de Rett est une maladie neurologique d’origine génétique. Il atteint quasi-exclusivement le sexe féminin en apparaissant entre 6 et 24 mois après la naissance. Pathologie très handicapante, le syndrome de Rett conduit à des déficiences physiques et intellectuelles graves, affectant presque tous les aspects de la vie quotidienne de l’enfant que ce soit sa capacité à parler, à marcher, à manger, à bouger les yeux … ou même à respirer facilement. L’enfant continue cependant à comprendre et à communiquer son humeur et son émotion à sa façon. UN HANDICAP LOURD, PRECOCE ET PROGRESSIF Le syndrome de Rett apparaît en général entre les 6 et 24 premiers mois de vie de la petite fille. Le développement psychique et moteur s’altère progressivement. De façon typique, la petite fille se frotte et tord ses mains de manière répétitive ; son intérêt pour son environnement se perd que ce soit à l’égard des personnes ou des objets. Ce tableau se complique souvent de crises d’épilepsie puis de l’apparition d’une scoliose. L’enfant peut vivre pendant des années, voire des dizaines d’années. La maladie n’est pas en effet mortelle, mais ce sont les nombreuses complications, surtout cardiorespiratoires et nutritionnelles, qui raccourcissent l’espérance de vie de ces petites filles. UNE GESTION MULTIDISCIPLINAIRE DE LA MALADIE Il n’existe pas de traitement pour le syndrome de Rett, la prise en charge se basant sur la gestion des symptômes. Il faut maintenir la mobilité du malade, prévenir les déformations squelettiques et conserver de bonnes positions par des appareillages portés jour et/ou nuit. Le maintien d’une certaine qualité de vie implique aussi la mobilisation équipes pluridisciplinaires comprenant, outre les médecins, des kinésithérapeutes, psychomotriciens, ergothérapeutes, diététiciens… Des traitements symptomatiques doivent par ailleurs être prescrits afin de soulager les différentes manifestations respiratoires, cardiovasculaires et les crises convulsives. PRISE EN CHARGE DES TROUBLES DE LA COMMUNICATION Les fillettes malades sont privées de communication verbale. Il faut alors essayer de comprendre ce qu’elles tentent de dire, en décodant les postures, les mimiques, les regards, les cris, les pleurs… On met en place ensuite une communication au moyen d’images représentant des objets, des personnes ou des actions de la vie quotidienne pour faciliter les échanges. UNE ORIGINE GENETIQUE MAIS NON HEEREDITAIRE Ce trouble concerne 1 naissance sur 10 à 15 000, ce qui représente 9 000 nouveaux cas chaque année dans le monde et une vingtaine au Maroc. Il provient de la mutation d’un gène sur le chromosome sexuel féminin X : plus précisément, il s’agit d’une néo-mutation, c’est-à-dire une mutation qui n’est pas portée et héritée de la mère ou le père, mais qui apparaît chez le futur bébé lors de son stade embryonnaire. DES ESPOIRS A L’HORIZON ? Ce syndrome fait l’objet actuellement d’une recherche médicale très dynamique. De nouvelles thérapeutiques, dont certaines sont en voie d’essai, permettront déjà certainement de réduire et maîtriser les problèmes cardiorespiratoires, sources des complications les plus graves. A plus long terme, tous les espoirs des familles reposent sur la thérapie génique susceptible d’apporter une amélioration significative et même la guérison. Son principe reposerait sur le remplacement du gène défectueux par l’introduction d’un gène normal et fonctionnel dans les cellules nerveuses, les neurones. LE DESARROI DES FAMILLES AU MAROC Comme le montre la description ci-dessus de tous ses aspects, cette affection implique de la part des parents au Maroc beaucoup de sacrifices, tant personnels que financiers. Bien des familles sont incapables d’y faire face avec une réelle efficacité et la prise en charge médicale est souvent défaillante. Face à toutes ces difficultés, des parents se sont mobilisés en créant, en 2015, l’association marocaine du syndrome de Rett. Leur énergie a permis de sortir de l’anonymat ce terrible mal mais il reste beaucoup à faire pour que tous ces enfants atteints puissent vivre dignement. L’ASSOCIATION MAROCAINE DU SYNDROME DE RETT (AMSR) L'association a été créée en 2015 par Monsieur El Mokhtar Mustapha. Elle a organisé sa première journée d'information et de sensibilisation à Rabat en mars 2017. El Mokhtar Mustapha EST EGALEMENT MEMBRE FONDATEUR ET MEMBRE DU BUREAU DE L’ALLIANCE DES MALADIES RARES AU MAROC Dr MOUSSAYER KHADIJA الدكتورة خديجة موسيار Spécialiste en médecine interne et en Gériatrie en libéral à Casablanca. Présidente de l’Alliance des Maladies Rares au Maroc (AMRM) et de l’association marocaine des maladies auto-immunes et systémiques (AMMAIS), Vice-présidente du Groupe de l’Auto-Immunité Marocain (GEAIM) SITES UTILES Orphanet : Grand site de référence sur les maladies rares, destiné aux professionnels et au grand public : https://www.orpha.net/consor/cgi-bin/index.php ALLIANCE maladies rares : http://www.alliance-maladies-rares.org/ EURORDIS http://www.eurordis.org/
Dr Moussayer khadija Dr Moussayer khadija

Dr Moussayer khadija

Dr MOUSSAYER KHADIJA الدكتورة خديجة موسيار Spécialiste en médecine interne et en Gériatrie en libéral à Casablanca. Présidente de l’Alliance Maladies Rares Maroc (AMRM) et de l’association marocaine des maladies auto-immunes et systémiques (AMMAIS), Vice-présidente du Groupe de l’Auto-Immunité Marocain (GEAIM)


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Chapter 3: The Latticework Theory- Reality as an Interdependent, Multi-Layered System 209

Satta Abraham, 19 h.
- Philosophy -
2.5 min read.
The conceptual framework commonly referred to as “Latticework Theory” integrates formal ontological analysis with applied epistemic reasoning. Willard Van Orman Quine’s analytic ontology, as outlined in "On What There Is" (1948), establishes rigorous criteria for identifying entities, categories, and relations within complex systems, providing a foundation for understanding which elements and interactions are structurally significant. Charlie Munger’s notion of a “latticework of mental models,” as articulated in his speeches and compiled in "Poor Charlie's Almanack" (2005), complements this by advocating for the disciplined integration of knowledge across domains to improve strategic decision-making under uncertainty. Together, these perspectives underpin a framework in which authority, information, and incentives propagate across layers of agents and institutions, producing outcomes that cannot be inferred from the isolated properties of components. Deviations at any node can be corrected when feedback is accurate, timely, and actionable. Failures occur when feedback is impaired, misaligned, or ignored. This framework provides a lens for analyzing industrial operations, national governance, financial systems, and technological risk in a unified, empirically grounded manner. The Toyota Production System (TPS), developed by Taiichi Ohno and detailed in "Toyota Production System: Beyond Large-Scale Production" (1988), exemplifies this framework at the operational level. TPS integrates authority, information, and incentives to align local actions with system-level objectives. The andon system, which allowed assembly line workers to halt production upon detecting defects, transmitted local observations directly to organizational decision nodes, enabling immediate corrective action. Empirical analyses, including studies of manufacturing efficiency, demonstrate that this configuration reduced defect propagation, accelerated problem resolution, and increased overall reliability compared to designs that optimized individual workstations independently. For instance, companies implementing TPS principles have reported defect rate decreases of around 60 percent, reflecting the structural alignment of authority, information, and incentives rather than isolated interventions. Singapore under Lee Kuan Yew illustrates the same principle at the national level. Between 1965 and 2020, per-capita GDP rose from approximately $517 to $61,467 in current U.S. dollars. By 2020, public housing coverage reached approximately 78.7% of resident households. Scholarly analyses attribute these outcomes to a central coordinating constraint: administrative meritocracy combined with credible enforcement. Recruitment and promotion emphasized competence and performance, anti-corruption measures ensured policy credibility, and social and industrial policies aligned skill formation, investment, and housing. These mechanisms were mutually reinforcing, producing system-level outcomes that cannot be explained by any single policy instrument but rather by ontological reasoning. Financial markets and strategic advisory practice demonstrate analogous dynamics. Many successful hedge fund managers and macro investors, such as George Soros (who studied philosophy with a strong historical focus) and Ray Dalio (who emphasizes historical pattern recognition in his investment principles), draw on deep historical expertise. Studies and industry insights highlight the value of humanities backgrounds in finance, with hedge funds actively recruiting liberal arts graduates for their ability to provide broader contextual understanding. This expertise enables pattern recognition across interacting variables, resource constraints, institutional incentives, technological change, political legitimacy, leadership behavior, and stochastic shocks, while facilitating analogical judgment about systemic regimes. George Soros’s concept of reflexivity formalizes the empirical reality that market prices and participant beliefs mutually influence one another. In feedback-dominated systems, quantitative models fail unless interpreted in historical and structural context. Historical insight therefore provides an advantage in long-horizon investing, geopolitical risk assessment, and capital allocation, as evidenced by the track records of such practitioners. The Boeing 737 MAX incidents of 2018 and 2019 provide a negative case that clarifies the ontology’s conditions. Investigations revealed that the MCAS system relied on single-sensor inputs, information about its behavior and failure modes was inconsistently communicated to operators, and engineering authority was constrained by commercial and schedule pressures. Incentives prioritized rapid certification and cost containment over systemic reliability. Local anomalies propagated to produce two hull-loss accidents with 346 fatalities. Analysis demonstrates that robust interconnection alone is insufficient. Outcomes depend on the alignment of authority, accurate information, and incentive structures that empower corrective action. Across manufacturing, national governance, finance, and technology, the same structural principle emerges: effective outcomes require the alignment of authority, information, and incentives, with feedback channels possessing sufficient fidelity and remedial capacity. Misalignment in any dimension produces fragility and amplifies errors. The Orbits Model operates within this substrate, with inner orbits requiring empirical validation and outer orbits constrained by systemic coherence. Empirical evaluation relies on archival records, institutional data, and observable system outcomes, providing a unified framework for analyzing complex adaptive systems. The Latticework framework thus integrates ontology, applied epistemics, and structural empirics, combining theoretical rigor with practical observation across domains.

Theosophy 259

Tupan, 22 h.
Theosophy is a spiritual movement that emerged in the late nineteenth century with the ambition of bringing religion, philosophy, and science into a single, coherent vision of truth. Drawing on both Eastern and Western mystical traditions, it promotes the idea of a timeless or “perennial” philosophy underlying all world religions. Central to this outlook is the belief that the soul evolves over long cycles of reincarnation and karma, gradually awakening to deeper spiritual realities. The movement was formally established in 1875 by Helena Petrovna Blavatsky (1831-1891) and her collaborators with the founding of the Theosophical Society, and it went on to shape many of the spiritual, philosophical, and artistic currents of the modern era. At the heart of Theosophical thought is the idea of a divine, impersonal Absolute that lies beyond the limits of human understanding—an idea comparable to the Hindu concept of Brahman or the Neoplatonic One. From this unknowable source, all levels of existence are said to unfold, descending through a hierarchy of spiritual planes and beings until they manifest in the material world. This cosmological vision reflects strong influences from Indian philosophy, especially Vedanta and Buddhism, while also incorporating elements of Western esoteric traditions such as Neoplatonism, Hermeticism, and Kabbalah. A defining feature of Theosophy is its emphasis on spiritual evolution. In The Secret Doctrine (1888), Blavatsky’s most influential work, she presents an elaborate account of planetary and human development governed by the laws of karma and reincarnation. According to this framework, humanity is currently passing through the fifth of seven “root races,” each representing a stage in the unfolding spiritual and psychic capacities of the species. The ultimate goal is a conscious return to divine unity, achieved through inner transformation and esoteric knowledge. Blavatsky maintained that her teachings were not purely her own but were inspired by highly advanced spiritual beings known as the Mahatmas or Masters. Said to live in remote regions of the world, these adepts were described as guardians of ancient wisdom and exemplars of humanity’s spiritual potential. Whether understood literally or symbolically, they expressed the Theosophical ideal of enlightenment and supported the Society’s mission of awakening latent spiritual capacities in all people. The influence of Theosophy reached well beyond the boundaries of the Theosophical Society itself. It played an important role in introducing Western audiences to ideas such as karma, reincarnation, and subtle energy systems, and it helped spark broader interest in Eastern religions. Its impact can be seen in the work of artists like Wassily Kandinsky (1866-1944), composers such as Gustav Holst (1874-1934), and spiritual thinkers including Rudolf Steiner (1861-1925), who later founded Anthroposophy, and Jiddu Krishnamurti (1895-1986), who was once proclaimed a World Teacher before ultimately distancing himself from the movement. Despite internal disagreements and the often complex nature of its teachings, Theosophy laid important groundwork for the later New Age movement and for modern forms of spiritual pluralism. Its effort to present a shared mystical heritage across cultures anticipated contemporary conversations linking science and spirituality, psychology and mysticism, and Eastern and Western worldviews. In this sense, Theosophy is more than a historical curiosity. It represents an ambitious attempt to reinterpret ancient wisdom for a modern world, grounded in the belief that spiritual truth is universal and that humanity’s deeper purpose lies in awakening to its own divine origins.