Exposomics: Lifelong Environmental Exposures and Health Outcomes with Dr. Jacob Galan
During this conversation we explore the concept of the exposome, which encompasses all environmental exposures a person experiences over a lifetime. The discussion covers how mass spectrometry helps analyze these exposures and sheds light on gene-environment interactions contributing to health outcomes. We examine how environmental toxins are linked to chronic diseases and highlight how cultural and dietary habits shape individual exposure profiles. The conversation also discusses how artificial intelligence is transforming exposomic research, offering the potential for new health insights through advanced analytics.
We address the complexities involved in studying exposomics: the significance of protein structures, innovations in biological research methods, and improvements in mass spectrometry that provide richer data for analysis. Challenges such as finding exposomic markers and detecting elusive ‘ghost molecules’ are considered, as well as the interactions between environment and hormonal health—like changes in testosterone levels. They discuss the promising future of exposomics, focusing on integrating AI and biomonitoring to better understand and manage the real-life impact of environmental exposures on health.
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