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L’étrange syndrome de l’odeur du poisson pourri 1651

Le syndrome de l’odeur du poisson pourri, appelé la triméthylaminurie, est un désordre métabolique rare où l’organisme est incapable de transformer une substance volatile mal odorante (la triméthylamine) en une autre sans odeur (oxyde de triméthylamine). Cette pathologie est connue en anglais sous le nom de Fish odor syndrome » (FOS) La triméthylamine (TMA) provient de certains aliments notamment les poissons de mer, les cacahuètes, les œufs et certains légumes. En l’absence de sa dégradation, elle s’accumule dans l'organisme et s’évapore par la sueur, l'urine et l'expiration, avec une forte odeur de poisson. LES CAUSES C’est une défaillance génétique de l’enzyme qui dégrade la TMA produite elle-même de la dégradation bactérienne intestinale d’aliments riches en ses précurseurs (choline, lécithine et carnitine). La TMA ainsi produite dans l’intestin sera rapidement transformée dans le foie et éliminée dans les urines sous forme d’oxyde de TMA. L’enzyme peut être totalement absente et la maladie s’exprime alors chez les enfants dès la diversification alimentaire. Si cette absence est partielle, les mauvaises odeurs sont intermittentes. Les personnes atteintes ont deux copies du gène défectueux . Les parents eux-mêmes peuvent n'avoir qu'une seule copie du gène défectueux et la pathologie sera transmise uniquement si les deux parents sont tous les deux porteurs d’une ou deux copies du gène défectueux ; ce qui signifie qu'une personne atteinte ne transmettra la maladie que si son partenaire est porteur. LES SIGNES Une odeur corporelle de poisson extrêmement désagréable que le corps dégage par la sueur, l’urine, la salive et l’haleine et même l’air expiré. L’intensité de cette odeur est variable d’une personne à l’autre et avec le temps. Ces symptômes difficiles à vivre peuvent entraîner un isolement, de l’anxiété et la dépression. On estime que plus de 200 personnes en seraient touchées dans le monde. LE TRAITEMENT DE CE SYNDROME Il n’existe actuellement aucun traitement curatif de la maladie. Les symptômes peuvent être fortement atténués par l’éviction de certains produits riches en TMA et ses précurseurs. Certains antibiotiques sont utiles en cures courtes pour réduire l’activité microbienne intestinale. Se laver fréquemment avec un savon acide et faire des exercices intenses avec sudation suivis par un lavage permet aussi une réduction des odeurs. Dr MOUSSAYER KHADIJA الدكتورة خديجة موسيار Spécialiste en médecine interne et en Gériatrie, Présidente de l’association marocaine des maladies auto-immunes et systémiques (AMMAIS), Présidente de l’Alliance Maladies Rares au Maroc (AMRM) اختصاصية في الطب الباطني و أمراض الشيخوخة رئيسة الجمعية المغربية لأمراض المناعة الذاتية و والجهازية , رئيسة ائتلاف الأمراض النادرة المغرب BIBLIOGRAPHIE - S. Nicolas and al, Le « Fish odor syndrome » : une maladie socialement invalidante - Fish odor syndrome : A socially disabling disorder, La Revue de Médecine Interne Volume 43, Issue 3, March 2022, Pages 178-180 https://doi.org/10.1016/j.revmed.2021.12.010 - Qu’est-ce que le syndrome de l’odeur du poisson ? Fréquence Médicale https://www.frequencemedicale.com/oncothoracique/patient/25623-Qu-est-ce-que-le-syndrome-de-l-odeur-du-poisson - Messenger J, Clark S, Massick S, Bechtel M. A review of trimethylaminuria: (fish odor syndrome). J Clin Aesthet Dermatol. 2013 Nov;6(11):45-8. PMID: 24307925; PMCID: PMC3848652. OVERVIEW Trimethylaminuria, or fish odor syndrome (FOS), is a condition characterized by the presence of trimethylamine (TMA)—a tertiary amine whose odor is described as resembling that of rotting fish—in the urine, sweat, and expired air. POUR EN SAVOIR PLUS, D’AUTRES EXEMPLES DE MALADIES TRES RARES On estime qu’une maladie est rare lorsqu’elle touche une faible fraction de la population. En Europe, le seuil est fixé à moins d’une personne sur 2 000. Certaines de ces pathologies ne peuvent concerner que quelques centaines de personnes dans le monde. Ainsi à titre d’exemple : Progéria La progéria, est une maladie génétique extrêmement rare qui accélère le vieillissement des nouveau-nés. Sa prévalence est exceptionnellement faible : 1 nouveau-né sur 7 000 000. Il n’y a pas de remède pour cette maladie génétique et la plupart des patients décèdent avant l’âge de 13 ans, atteignant exceptionnellement l’âge de 20 ans. Atrophie hémifaciale progressive Cette maladie affecte la peau, les muscles faciaux et les structures osseuses du visage. Elle n’implique généralement qu’un seul des plans de la tête (d’où son nom, hémifacial). L’atrophie unilatérale donne au patient un aspect très étrange, comme si la moitié de son visage était en train de se décomposer. Il n’y a pas de traitement pour cette affection, mais on emploie souvent la chirurgie esthétique pour en réduire le phénomène L'ostéogenèse imparfaite L’ostéogenèse imparfaite, ou maladie « des os de verre », est une affection génétique, caractérisée par une fragilité osseuse et une faible masse osseuse à l’origine de fractures à répétition, survenant à la suite de traumatismes bénins L'on compte environ un malade pour 10 000 à 20 000 personnes et elle ne peut donc être considérée comme "très rare" L’ostéogenèse imparfaite chez l'enfant ainsi que ces troubles annexes peuvent être traitées par différents traitements médicaux et chirurgicaux : traitement des fractures : en évitant les immobilisations trop rigides et trop prolongées, lutte contre la douleur des fractures du tassement vertébral par des médications ou par des contentions, apport régulier de vitamine D avec des ajouts de calcium si besoin… L’ALLIANCE DES MALADIES RARES AU MAROC (AMRM) Depuis sa création en 2017, l’ALLIANCE travaille au quotidien avec beaucoup d’associations marocaines spécifiques pour une maladie donnée. Elle a d'ailleurs déjà signé des conventions de partenariat « stratégiques » avec 12 associations de patients : 1/Association de syndrome de Rett (AMSR) , 2/ Association de Solidarité avec les Enfants de la Lune au Maroc (A.S.E.L.M.) , 3/ Association de l’amyotrophie spinale (SMA) , 4 / association SOS Pku , 5/ association marocaine des malades d’angioedème héréditaire (AMMAO) , 6/ Association Marocaine pour la Santé de l’Enfant et de la Mère (AMSEM) , 7/ Association S.O.S Marfantime (S.O.S.M.) , 8/Association Prader Willi Maroc (P.W.M.) , 9/ Association Flamme d'Espoir pour les Autistes et les Patients atteints de la PKU , 10/ Association marocaine pour les enfants souffrant d’ostéoporose (Ostéogenèse imparfaite) A.M.E.O.S , 11/ Association Marocaine de Mucoviscidose (AMM) , 12/ Association Fragile X Maroc (FxMa) . Au sein du bureau de l’Alliance, la présidente est entourée notamment du : Dr Fouzia Chraibi, ,Vice –Présidente , Dr Mounir Filali, Secrétaire général, M Mohammed Elaidi, Secrétaire général adjoint, Mme Najat Kababi, Trésorière et de Mme Fatima Lahouiry, Trésorière adjointe
Dr Moussayer khadija

Dr Moussayer khadija

Dr MOUSSAYER KHADIJA الدكتورة خديجة موسيار Spécialiste en médecine interne et en Gériatrie en libéral à Casablanca. Présidente de l’Alliance Maladies Rares Maroc (AMRM) et de l’association marocaine des maladies auto-immunes et systémiques (AMMAIS), Vice-présidente du Groupe de l’Auto-Immunité Marocain (GEAIM)


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Sacred Geometry 163

Sacred geometry is the study of universal patterns, proportions, and forms that shape the structure of the cosmos. Based in both mystical philosophy and natural law, it proposes that certain geometric principles—such as the circle, the triangle, the square, and the spiral—are not mere abstractions of the human mind, but archetypal patterns embedded in the very fabric of existence. From the crystalline structure of minerals to the arrangement of galaxies, from the spiraling of galaxies to the loops of a seashell, sacred geometry reveals the fundamental harmony that unites all levels of being, from the microcosm to the macrocosm. Historically, sacred geometry has been used in nearly every advanced civilization. In ancient Egypt, temples were constructed in accordance with geometrical harmonies to mirror the cosmic order and to serve as portals between the earthly and the divine. In Greece, Pythagoras and his initiates viewed numbers and forms as the essence of all reality, with the tetractys—a triangular arrangement of ten points—symbolizing the unfolding of the universe from unity into multiplicity. Platonic solids, which are the only five regular polyhedra that exist in three-dimensional space, were seen as the geometric building blocks of the classical elements: earth (cube), air (octahedron), water (icosahedron), fire (tetrahedron), and ether or spirit (dodecahedron). The circle is the most fundamental and infinite of all shapes, representing unity, eternity, and the divine source. From it circle arises the Vesica Piscis, formed by the intersection of two circles, symbolizing the intersection of spirit and matter, or heaven and earth. This sacred figure originates other key patterns such as the Seed of Life, Flower of Life, and Tree of Life, each a progressively complex map of creation and emanation. These patterns are found carved into sacred sites around the world, not as decoration, but as invocations of cosmic harmony encoded in symbol. At a more esoteric level, sacred geometry is not only the structure of physical matter but also the architecture of consciousness. Every line and angle becomes a glyph of spiritual truth. In the Kabbalistic Tree of Life, for example, the Sephiroth are arranged in a precise geometric pattern that mirrors the process of divine emanation from the Infinite (Ein Sof) into the manifested world. In Islamic architecture, intricate geometric mosaics reflect the infinite within the finite, pointing to the divine through abstraction and mathematical beauty. In Eastern mandalas, sacred geometry functions as both map and mirror—a diagram of the universe and a guide to inner stillness. The mystical power of sacred geometry resides in its ability to bridge the material and the metaphysical. Geometry is not only a tool for measuring space but a sacred science that unveils the divine intelligence at work in all things. To contemplate these forms is to enter a state of resonance with the universal order. When one meditates upon the proportions of a golden spiral or the interlocking symmetry of a mandala, the soul begins to remember its own original harmony. Sacred geometry is not a human invention, but a revelation—a language through which the cosmos speaks to itself. It is the alphabet of creation, the blueprint of form, and the silent song of order hidden in the chaos of appearances. Whether found in cathedrals or pinecones, in the fractal of a fern or the plan of a pyramid, these shapes serve as portals to remembrance. They whisper that behind all things lies a unified design, and to perceive it is to glimpse the mind of the divine.

Le Monde and Morocco: Deconstructing a Biased View of a Revered Monarchy... 378

The newspaper Le Monde, founded on the recommendation of General De Gaulle in the context of the Second World War in 1944, is internationally renowned for its investigative journalism and analytical capability. However, it often displays a biased approach when it focuses on the Kingdom of Morocco. The article published on August 24, 2025, titled "In Morocco, an atmosphere of end of reign for Mohammed VI," symptomatically illustrates this tendency, which deserves a response by also recalling the conflictual relationship the newspaper has had with the Kingdom almost since its inception. The impression is that it is probably the fact that Morocco is a Kingdom that bothers or disturbs the paper. The relationship to monarchy, particularly from the French left, is not unrelated to this ideological stance. For a long time, Le Monde's editorial coverage of Morocco has avoided neutrality. Since the time of Hassan II, the paper frequently adopted a critical tone, sometimes unjustly severe, offering a European reading framework that often reduced the complex Moroccan political reality to a caricature. Between interpretations disconnected from reality and unfounded insinuations, the treatment of the country has often been limited to a black-and-white vision, marginalizing the concrete nuances of its evolutions and its centuries-old history. It must be reminded that the Kingdom, as a nation-state, existed long before what is today called France. It therefore has its own codes and its own evolution and worldview. The newspaper's stance, inherited from a postcolonial reading marked by a basic socialism fixed on the image of an immutable authoritarian power and a society on the brink of upheaval. Journalists seem to relive by proxy the years before 1789. Conflations and romanticized interpretations are the rule. Returning to the article, would the King of Morocco be a misunderstood sovereign? Is the Kingdom, for its part, so little known to the journalists of "Le Monde"? Would the secular Moroccan people simply be a copy of the people of medieval France? Or is it simply an ideological stance blinding the paper? The mention of an "atmosphere of end of reign" in the recent article betrays profound ignorance coupled with a dubious hypothesis. In reality, no tangible sign of decline emerges, quite the opposite. The Moroccan people show notable attachment to their monarchy perceived as an essential pillar for stability, development, and national cohesion. A simple observation of social networks would have spared the authors from such errors, for since 1999, under the impetus of King Mohammed VI, Morocco has achieved important reforms. These are advances that took France two centuries. How can one forget to mention the country’s major achievements in such a short time: - Sustained economic growth in several strategic sectors, generating jobs and sustainable prospects. - Modernization of the family code (Moudawana), a symbol of major social progress, particularly regarding women's rights. - Adoption of a transitional justice policy favoring reconciliation and healing historical wounds. - Establishment of mandatory medical coverage, expanding access to healthcare for all. - Assertive diplomacy recognized on the African continent and internationally, demonstrating a well-thought-out, forward-looking strategy. - The Kingdom is preparing to host the Football World Cup, a sign of great trust from the international community. These successes, however glaring, are overlooked by the authors because they contradict a sensationalist narrative of monarchical decline which appeals to some French circles nostalgic, under the surface, for the monarchy they killed. The article recklessly mixes rumors, outdated clichés, and baseless hypotheses, portraying power as frozen, aging, and oppressive. The author consciously ignores the multifaceted reality of a country at the crossroads of ancient traditions and sustained modernization. The depiction of a "twilight" reign reflects a condescending gaze, reminiscent of dominant stereotypes that often reduce the Arab and African world to narratives of instability and decline. Contrary to the dark picture painted by Le Monde, contemporary Morocco under Mohammed VI pursues a dynamic trajectory, marked by concrete progress and real stakes, aligned with popular expectations. Rejection is not expressed through a distancing from the monarchy, but by a demand for thoughtful, gradual reforms that respect traditions and institutions. In this context, speaking of "end of reign" stems from a mistaken reading that distorts the actual function and role of monarchy today. Here, it is essential to claim rigorous journalism based on documentary research and pluralism, finally freeing itself from postcolonial reflexes and a condescending gaze. Morocco cannot be reduced to an exotic subject of study or a testing ground for imported scenarios. More than a relic, the monarchy embodies a central lever of a nation in motion, led by lucid and committed leadership. Le Monde’s editorial past seems to weigh heavily on its analysis of current events in Morocco. By assertively stating an "atmosphere of end of reign," the article disconnects its diagnosis from the social, economic, and political realities shaping the Kingdom. The achievements show a sincere will to articulate traditions and modernity, stability and popular aspirations, in a difficult regional environment that the country has managed with discernment. By omitting these elements, favoring unfounded rumors and finished stereotypes, the text promotes an alarmist narrative that harms both truth and constructive dialogue, feeding prejudices inherited from an outdated postcolonial vision. Thus, far from a predicted decline, Morocco traces a path based on conscientious leadership, rooted in a millennia-old history and attentive to current challenges, looking towards a hopeful future. It is time for Le Monde to renew its gaze with honesty and respect, going beyond clichés and integrating the diversity of the Moroccan voice. The arrogance of an external view must never outweigh lived reality. Readers of this newspaper, as with others when it comes to Morocco, deserve balanced, non-partisan, and open information reflecting the richness and depth of a society and a Kingdom in full transformation, faithful to its institutions and its sovereign.

Ukraine and Sudan: Two Conflicts, Two Different Perspectives... 461

The entire Western world gathered in Washington a few days ago. Since his return, President Trump has been trying to save what remains of Ukraine, and the Europeans genuinely do not want this to happen behind their backs. Unable to play a decisive role, they at least want to be present. Their credibility is at stake, and above all, their image before the rest of the world. Overheated by a Europe whose reach exceeds its power—a Europe increasingly powerless—Ukraine has endured and waged a war it believed it could win with Western support. To date, it has lost 20% of its territory, and it is far from over. Instead of dealing directly with Vladimir (Putin), Volodymyr (Zelensky) thought it wiser to seek support from those who had already been insufficient since delegating their defense to NATO, and thus to the United States. The Europeans will learn this the hard way: one cannot wage war without the means to do so. That same world remains silent about what is happening in Sudan. It is considered less “interesting.” Two generals, generals in name only, have launched a militarized competition to seize power, just days after signing an agreement to share it. Since then, the situation has deteriorated. Every day, lives are lost, women are raped, and millions of people wander the desert, their only refuge. For the Western world, perhaps—I emphasize perhaps—they are just Africans, mostly believing themselves Arabs, killing each other. The war in Sudan, particularly in the Darfur region, remains one of the most tragic and deadly conflicts since its outbreak in April 2023. This war mainly pits two rival forces against each other: the Sudanese Armed Forces (SAF), led by Abdel Fattah al-Burhan, and the Rapid Support Forces (RSF), commanded by Mohamed Hamdan Dagalo, known as “Hemedti,” former leader of the Janjaweed militias. The latter, along with their allied Arab militias, are responsible for massive massacres, especially targeting the Massalit people and other non-Arab groups in Darfur. In essence, those who consider themselves Arab are killing and driving from their lands those they do not recognize as their own. The BBC has just released an investigation and documentary on this subject, which should stir collective conscience, if any human conscience remains willing to watch. The conflict is primarily a power struggle between the two military leaders who, it should be recalled, had signed a pact to govern the country jointly. The sudden slide into armed clashes has spread to several regions, notably Darfur, where the RSF and their allies stand accused of grave abuses. The Janjaweed, militias identifying as Arab and formerly supported by former Sudanese President Omar al-Bashir, are active again under the RSF banner, committing ethnic-based violence openly. Also involved are the Sudan Liberation Movement (SLA/SLM), the historic rebels of Darfur, fragmented between Minni Minnawi and Abdelwahid Mohamed al-Nur. The scale of the massacres is terrifying. According to the UN, in Al-Geneina, the capital of West Darfur, between 10,000 and 15,000 Massalit civilians were killed between June and November 2023 by the RSF and allied Arab militias. More broadly, over 150,000 have died in two years throughout Darfur, with 13 million displaced—half the Sudanese population—pushed to the brink of famine. NGOs like Doctors Without Borders warn of imminent massacres in cities such as El-Fasher, heavily besieged. The violence also includes destruction of civil infrastructure, schools, and mosques. Systematic sexual violence is another tragic facet of the massacre. Following a deadly attack a few days ago, Doctors Without Borders just closed the only hospital still operating in Zalengei, the regional capital, making any medical activity impossible. This is not the first hospital to be forced to shut down. Despite overwhelming evidence of war crimes and crimes against humanity, the international response remains mostly ineffective. Although the United States and the UN officially acknowledge the severity of the genocide, their direct interventions and sanctions remain timid. The African Union and the UN struggle to deploy forces capable of enforcing peace and upholding international law. Arab countries exert no notable pressure on Hemedti or Burhan, the latter having long wielded significant influence in Sudan. This silence is interpreted by many observers as complicity, seen as a form of institutional racism that devalues African lives, especially those of the Massalit victims of the RSF. The fact that Hemedti and his allies claim an “Arab” identity while attacking so-called “African” groups, according to some, contributes to the indifference of Arab nations, more preoccupied with their regional dynamics than human rights. International Muslim organizations have also failed to take a forceful stand, despite frequent religious instrumentalization by the warring parties. The conflict is also marked by a profound religious contradiction: murder, injustice, and war among Muslims are explicitly condemned by Islam, except in cases of self-defense or struggle against oppression. Yet, the massacres in Darfur are regularly denounced as contrary to these principles by Muslim intellectuals and religious leaders, though these condemnations have had little tangible effect on the violence. This crisis has triggered the world’s largest current humanitarian emergency, with 13 million displaced. Access to medical care, food, and shelter remains grossly insufficient. Civilians live in extreme insecurity, caught in ethnic and political struggles manipulated by power-hungry warlords. The international community, Arab countries, and Muslim actors appear to be shirking their responsibilities, allowing this tragedy to continue in alarming silence. This situation challenges not only global collective conscience but also the real capacity of international institutions to protect the most vulnerable populations from such vast violence. The situation in Darfur and greater Sudan is a stark and urgent call for attention. The hope remains that the wars in both Ukraine and Sudan will end swiftly, as in both cases it is innocent generations paying the price of violent conflict.

Love 517

Love! Love is a destiny We hardly choose the moment to love It happens one evening or one morning It happens by pure chance It leaves you confused and haggard One day when you least expect it You didn't see it coming from afar It happens in the blink of an eye... Without an appointment... It makes you soft... It makes you lose your mind... It makes you run away from home Like fire, it burns you with passion Love at first sight is legion You'll get your share, your ration Without logic... But it's beautiful despite everything we endure It's a pure feeling When it's sincere It's magical It's fantastic Despite its pains and sorrows, its sleepless nights Until morning It's the elixir of life It's endless ecstasy... It happens to you by magic... Content in loving takes you away from everything... It besieges you from everywhere! It takes over! It will drive you crazy sooner or later!!! Dr. Fouad Bouchareb El Medano / Tenerife August 24, 2025 Inspired by a text by Jalal Eddine Erroumi Arabic and Arabic All rights reserved