Think Forward.

GERIATRIE : LA NUTRITION FACE AU VIEILLISSEMENT PHYSIOLOGIQUE DES PERSONNES ÂGÉES - PARTIE 1

«QUAND ON AVANCE EN ÂGE, MIEUX VIVRE C’EST MIEUX SE NOURIR» L’équilibre nutritionnel de la personne âgée (PA) est plus précaire car tributaire de modifications physiologiques et de l’émergence de pathologies. Les personnes âgées ont tendance par ailleurs à diminuer leur apport alimentaire sans que leurs besoins énergétiques ne soient réduits : leurs réserves étant amoindries, tout incident rompt un équilibre déjà précaire et la dénutrition fait son apparition. L'IMPACT DU VIELLISSEMENT PHYSIOLOGIQUE SUR LA NUTRITION Avec l’âge, l’altération des perceptions des odeurs et du goût stimule moins l’appétit : la capacité discriminative s’affaiblit d’où une difficulté à identifier les aliments ; le seuil de détection des 4 saveurs de base augmente (multiplié par 11,6 pour le salé, 7 pour l’amer, 4,3 pour l’acide et 2,7 pour le sucré). Près de 400 médications (anti-inflammatoires, antidiabétiques oraux, inhibiteurs de l’enzyme de conversion…), des carences en zinc ou en vitamine B3, la cirrhose du foie ou la déshydratation perturbent le goût. La malnutrition aggrave ces déficiences, ralentissant ainsi le renouvellement cellulaire indispensable à la régénération des acteurs sensoriels. La perte d’appétit découle aussi d’une sénescence des glandes salivaire. Les aliments n’étant plus correctement imbibés, les molécules porteuses de saveurs appétissantes sont moins actives. De plus, la dégradation dentaire et la prédilection pour des aliments plus liquides diminuent les mouvements masticatoires ce qui va encore réduire cette sécrétion. La sécheresse buccale (xérostomie) est alors fréquente, exacerbée par de nombreux médicaments (diurétiques, benzodiazépines, antihistaminiques…), elle va favoriser les caries dentaires, les mycoses buccales et œsophagiennes, occasionnant des brûlures lors de l’ingestion et, in fine, gênant l’élocution et la déglutition. La muqueuse gastrique, en s’atrophiant, sécrète moins d’acide chlorhydrique, d’où une pullulation bactérienne consommatrice de nutriments (folates) et un retard à l’évacuation gastrique de 2 à 3 fois plus long, qui prolonge la phase d’anorexie post-prandiale. L’accélération plus importante chez la PA du transfert du chyme de la partie supérieure de l’estomac (le fundus) à la partie inférieure (l’antre) avec une distension précoce de cette dernière joue par ailleurs un rôle prépondérant dans le sentiment précoce de satiété. Un peptide, le CCK sérique (cholecystokime -pancreozymine), produit par le duodénum au cours du repas, stimule la sécrétion par le pancréas de la trypsine qui inhibe en retour la sécrétion de CCK. L’insuffisance pancréatique exocrine, liée à l’âge ou aggravée par une dénutrition, lève ce rétrocontrôle, d’où une production accrue de CCK à l’origine elle aussi d’une satiété précoce. La survenue plus fréquente chez la PA d’ulcères et de gastrites chroniques, en liaison avec une incidence plus élevée d’infection par Hélicobacter pylori, renforce encore le risque anorexique. Le vieillissement musculaire et la diminution du capital musculaire (sarcopénie) est un phénomène presque inéluctable qui commence à 40 ans pour l’homme contre 50 ans pour la femme. La perte -de 3 à 8 % tous les dix ans- s’accélère après 60 ans et réduit la musculature à 17% du poids du corps à 70 ans contre 30% à 30 ans. La composition en fibres du muscle se modifie : les fibres de type II, ou fibres blanches, à contraction rapide, mais peu résistantes à la fatigue, s’atrophient ; les fibres de type I ou fibres rouges, à contraction lente, générant peu de force, mais une forte endurance, sont moins affectées et leur densité serait même plus importante. Outre cette réduction de la force musculaire malgré une certaine préservation de l’endurance, le système nerveux contrôle moins bien ces contractions. Plusieurs facteurs génétiques, médicamenteux, nutritionnels ainsi que l’augmentation des cytokines (état inflammatoire provenant de l’accroissement de la masse grasse) conditionnent l’apparition de cette sarcopénie. Les hormones sexuelles joueraient aussi un rôle dans le contrôle de l’appétit au cours du vieillissement. La diminution des taux circulants de testostérone observée au moment de l’andropause induirait la perte d’appétit chez l’homme âgé et précipiterait le développement de la sarcopénie. À l’inverse, la réduction de sécrétion des œstrogènes à la ménopause protégerait les femmes de cette perte. Les répercussions de la sarcopénie sont considérables : risques infectieux par baisse des réserves protéiques nécessaires aux défenses immunitaires, chutes et fractures éventuelles compromettant l’autonomie de la PA… Un moindre volume musculaire expose aussi la PA aux troubles de la thermorégulation, la baisse de l’intensité du frissonnement qui en découle rendant la PA plus démunie face à l’exposition au froid. Dr MOUSSAYER KHADIJA الدكتورة خديجة موسيار Spécialiste en médecine interne et en Gériatrie en libéral à Casablanca. Présidente de l’Alliance Maladies Rares Maroc (AMRM) et de l’association marocaine des maladies auto-immunes et systémiques (AMMAIS), Vice-présidente du Groupe de l’Auto-Immunité Marocain (GEAIM) - REFERENCE MOUSSAYER KHADIJA Doctinews N° 25 Août/Septembre 2010, ACTUALISATION JUIN 2024 - POUR EN SAVOIR PLUS : La plupart des personnes âgees souffrent de maladies chronique le plus souvent d'origine auto-immune Les maladies auto-immunes résultent d’un dysfonctionnement du système immunitaire, censé nous protéger des agressions extérieures, qui va le conduire à s’attaquer à notre propre organisme. Elles constituent un important problème de santé publique du fait de leur poids économique et humain : 3ème cause de morbidité dans le monde après les maladies cardiovasculaires et les cancers, elles touchent en effet près de 10 % de la population mondiale et occupent le deuxième ou le troisième poste du budget de la santé dans beaucoup de pays. Enfin, dernier point méconnu mais pas le moindre, ces maladies concernent les femmes dans plus de 75 % des cas : une femme sur six en est atteinte au cours de sa vie ! Passons donc en revue ce que sont ces pathologies et les actions de l’associations AMMAIS UN PROCESSUS D'AUTODESTRUCTION DE L'ORGANISME Notre système immunitaire est composé notamment de cellules spécialisées comme les lymphocytes et de substances (les anticorps) chargées normalement de nous défendre contre toute attaque extérieure provenant de différents virus, bactéries, champignons et autres produits délétères. Lors d’une maladie auto-immune (MAI) ou à manifestations auto-immunes, des éléments de ce système se trompent d’ennemi et s’en prennent à nos tissus et cellules. Certains anticorps devenus nos adversaires s’appellent alors « auto-anticorps ». Au total, il existe près d’une centaine de ces troubles.
Dr Moussayer khadija

Dr Moussayer khadija

Dr MOUSSAYER KHADIJA الدكتورة خديجة موسيار Spécialiste en médecine interne et en Gériatrie en libéral à Casablanca. Présidente de l’Alliance Maladies Rares Maroc (AMRM) et de l’association marocaine des maladies auto-immunes et systémiques (AMMAIS), Vice-présidente du Groupe de l’Auto-Immunité Marocain (GEAIM)


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"The Ones"

We crave “the ones” that need salvation We crave “the ones” that face starvation Not for saving or comforting our souls The wall “the ones” they climb, brings them to us We are the rope, the strong rope they need. Tattered, frayed and a little torn but able to hold giants

Supernova

One of those sunless nights My feet planted firmly in the sky I will call your name Meandering through the stars See if gravity pulls us apart You might forget my soul An event without horizon Drink the poison of my hope I will swallow my reason He who wanted to elope In a supernova

Angioedema: "From localized swelling attacks to potentially fatal asphyxia"

Angioedemas are characterized by an accumulation of fluid in the mucous membranes and skin resulting in swelling of the face, limbs or genitals.They may carry a risk of asphyxiation when the throat is affected. ANGIOEDEMA OF ALLERGIC ORIGIN In the vast majority of cases, it is an angioedema of allergic origin, about 20% of the population are affected at some point in their life. Often associated with an urticaria, it can be caused by food, insect bite or drug. The treatment of this histamine angioedema is based on corticosteroids and antihistamine drugs. In the most severe cases (quincke's oedema), adrenaline is essential to avoid anaphylactic shock (spread of allergy throughout the body). THE HEREDITARY ANGIOEDEMA Angioedema may have another cause, often unknown : it is the hereditary bradykinic angioedema. This rarer form occurs most often during childhood or adolescence, edema develops gradually and recidivally in a few hours and persists for an average of 2 to 5 days and disappears without sequelae. The frequency and severity of seizures vary according to the patients and for the same patient according to the periods of life. Certain events such as dental procedures, infections, stress, pregnancy ... are the triggering factors of the crisis. The swelling may affect the abdomen, causing severe pain, nausea and vomiting as well as diarrhea. Laryngeal edema is life-threatening with a 25% risk of death in the absence of appropriate treatment. Even more rarely, bradykinetic angioedema exists in an acquired non-hereditary form, usually occurring in adults over 50 years of age and subsequent to another disease (autoimmune or cancerous) or to certain drugs such as antihypertensive drugs of the family of angiotensin converting enzyme inhibitors or antidiabetic agents.. The treatment of bradykin angioedema attacks is based on the use of drugs that are not yet available in Morocco (subcutaneous injections of icatibant or intravenous C1Inh concentrate). Tranexamic acid or danazol are basic treatments for the disease. THE MOROCCAN ASSOCIATION OF ANGIOEDEMA The Moroccan Association of Angioedema Patients (AMMAO), chaired by Mr. Imad Elaouni, was created in February 2018 by civil society people and members of the medical and paramedical profession with the aim providing information and awareness to the population about these pathologies as well as the unification of the efforts and the assistance to lend to the people suffering from them. Professor Laurence Bouillet, Professor of Internal Medicine and coordinator of the national reference center on angioedema in France, is the honorary president. AMMAO is also a member of the global network of angioedema -HAEI. -Dr Moussayer Khadija, medical doctor in internal medecine, chairwoman of the alliance of rare diseases in Morocco, vice-president of the Moroccan Association of Angioedema Patients (AMMAO), BIBLIOGRAPHIE - Isabelle Boccon-Gibod , Laurence Bouillet, MD , Clement Olivier, Clinical Characteristics of Hereditary Angioedema (HAE) Type III Patients Compared with Those with HAE Type I/II , JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 26/01/13, Doi : 10.1016/j.jaci.2012.12.791 - Laurence Bouillet, Diagnostic des angioedèmes héréditaires, La Presse Médicale, Volume 44, Issue 1, 2015, Pages 52-56, ISSN 0755-4982, https://doi.org/10.1016/j.lpm.2014.06.027. - Khadija Moussayer, Les angioedèmes en débat à Casablanca le 19 janvier 2019, Mescursus 29 Décembre 2018. https://medcursus.com/442/les-angioedemes-en-debat-casablanca-le-19-janvier-2019 - Khadija Moussayer, On estime que 2.000 personnes sont touchées par les angioedèmes bradykiniques au Maroc, Le Matin ma, 4 janvier 2024 https://lematin.ma/express/2022/maroc-compte-2000-cas-angioedeme-bradykinique/384170.html EL ANGIOEDEMA : "Desde los ataques de hinchazón localizados hasta la asfixia potencialmente mortal" El Angioedema se caracteriza por una acumulación de líquido en las mucosas y en la piel, lo que produce unhinchazón e inflamación de la cara, de las extremidades o de los genitales. Puede poner en peligro la vida del paciente, cuando afecta a la vía aérea. En la gran mayoría de los casos, es un angioedema de origen alérgico. Afecta a aproximadamente el 20% de la población en algún momento de su vida, y esta a menudo asociado a la presencia de una urticaria. Puede ser causado por un alimento, una picadura de insecto o un medicamento. El angioedema histamínicose trata concorticosteroides y antihistamínicos. En los casos más graves (edema de Quincke), la adrenalina constituye el tratamiento de elección para evitar el shock anafiláctico. Otra causa del angioedema, a menudo desconocida en Marruecos es : el angioedema bradiquínico hereditario. Se trata de una forma rara que ocurre con mayor frecuencia durante la infancia o la adolescencia. Los pacientes presentan edemas recurrentes que duran de 2 a 5 días y que desaparecen sin secuelas. Los episodios o ataques de la enfermedad se producen de forma impredecible y varían de un paciente a otro. Se conocen una serie de factores que pueden desencadenar los ataques como los procedimientos dentales, las infecciones de la esfera ORL, el estrés, el embarazo ... El hinchazón puede incluso afectar al abdomen, provocando dolores intensos, náuseas y vómitos, así como diarrea. El edema laríngeo es potencialmente mortal, con un riesgo de muerte del 25% en ausencia de un tratamiento adecuado. Una forma aún más rara es el angioedema bradiquínico adquirido no hereditario, cual ocurre generalmente en adultos mayores de 50 años, y es consecuencia de otra enfermedad (autoinmune o cancerosa) o de ciertos medicamentos como los antihipertensivos de la familia de losinhibidores de la enzima convertidora de angiotensina (IECA) o los antidiabéticos. El tratamiento de los ataques de angioedema bradiquínico consiste en el uso de medicamentos que aún no están disponibles en Marruecos (inyecciones subcutáneas de icatibant o administración intravenosa de concentrados de INH-C1). El ácido tranexámico o el danazol constituyen tratamientos de fondode la enfermedad.

Mastering the Art of Persuasion: Boost Your Interpersonal Communication Skills

This article presents a complete method for improving interpersonal communication through five separate strategies. The first intervention consists of active listening workshops, which emphasize the development of skills such as active listening, question framing, and paraphrasing. The second program focuses on empathy-building exercises, which use interactive activities, role-playing scenarios, and real-life experiences to foster empathy. The third component, Cultural Sensitivity Training, aims to provide learners with the information and abilities they need to navigate numerous communication landscapes by recognizing nonverbal clues and understanding different communication styles. Furthermore, as the fourth intervention, the study provides conflict resolution workshops, which provide practical skills and strategies for resolving disagreements constructively. Participants learn how to identify core reasons, effectively communicate concerns, and work on mutually beneficial solutions. Finally, through Mindfulness in Communication workshops, the fifth technique is incorporating mindfulness practices into communication. Deep breathing, meditation, and remaining present in talks are all addressed as ways to boost self-awareness and intentional communication. This multidimensional approach is intended to provide individuals with the skills and awareness needed for effective communication in a variety of personal and professional circumstances. Since 2009, I have gained practical experience in the field of interpersonal communication training, which has allowed me to develop these models.     I- Active Listening Workshops: Hold workshops or training sessions to improve your active listening skills. Many communication problems stem from misunderstanding the other person's point of view. Teach participants how to listen carefully, ask clarifying questions, and paraphrase to ensure they accurately understand the speaker's message. Active listening, an often overlooked skill in interpersonal communication, is the foundation of lasting connections. The Active Listening Workshops have been painstakingly constructed to transform this talent from a passive pastime into an art form. Participants are immersed in a dynamic learning environment in which they not only hear words but also identify the underlying emotions and intentions underlying the message. Individuals are coached through a series of interactive exercises to fine-tune their ability to ask probing questions that elicit deeper insights and understanding. To ensure that the listener fully understands the speaker's intended message, paraphrasing techniques are provided. The sessions go below the surface of communication, emphasizing the value of nonverbal clues and subtle nuances that frequently express more than words alone. 2. Empathy-Building Exercises: Develop activities that foster empathy among individuals. This could include role-playing scenarios, storytelling sessions, or even volunteering opportunities. By understanding and appreciating the feelings of others, people can develop stronger interpersonal connections. Empathy-building exercises represent a unique synergy between a friendly, approachable demeanor and the rigor of scientific inquiry. By creating a warm and inviting atmosphere, participants are encouraged to embark on a journey of emotional exploration. Through purposeful activities and real-world scenarios, individuals engage in a shared experience that transcends mere understanding, fostering a genuine connection with the emotions of others. 3. Cultural Sensitivity Training: In our diverse world, understanding and respecting different cultures is crucial for effective communication. Organize training sessions to raise awareness about cultural differences, non-verbal cues, and communication styles. This can help individuals navigate cross-cultural interactions with greater ease. In our interconnected global society, effective communication necessitates a nuanced understanding of cultural diversity. Cultural Sensitivity Training stands as an imperative initiative, offering participants a comprehensive framework to navigate the intricate tapestry of cross-cultural communication. 4. Conflict Resolution Workshops: Conflict is inevitable, but effective resolution is a skill that can be learned. Offer workshops on conflict resolution techniques, teaching participants how to identify issues, express their concerns constructively, and work towards mutually beneficial solutions. This can significantly improve workplace dynamics and personal relationships. In the intricate dance of human relationships, conflicts are inevitable, yet the manner in which they are navigated can profoundly impact the fabric of interpersonal dynamics. Conflict Resolution Workshops are designed as a strategic intervention, providing participants with a robust toolkit to transform conflicts from sources of discord into catalysts for constructive growth. 5-Mindfulness in Communication: Amidst the clamor of modern life, where distractions abound and conversations often teeter on the precipice of haste, the integration of mindfulness into communication emerges as a transformative paradigm. Mindfulness in Communication sessions are crafted as sanctuaries of self-awareness and intentional engagement, offering participants a reprieve from the tumultuous cadence of contemporary interaction. At the heart of these sessions lie practices such as deep breathing, meditation, and the cultivation of present-moment awareness. Participants are gently guided to observe their thoughts and emotions without judgment, fostering a heightened consciousness of their own communicative patterns. By infusing mindfulness into the very fabric of communication, individuals learn to anchor themselves in the present during interactions. This deliberate presence not only enhances the quality of listening but also empowers speakers to express themselves with clarity and authenticity. These sessions extend beyond the immediate realm of communication, transcending into the broader landscape of emotional regulation. As participants develop a capacity for mindfulness, they gain a profound understanding of the intricate interplay between thoughts and words, fostering a sense of calm and poise even in challenging conversations. The impact of mindfulness in communication is far-reaching. Beyond individual empowerment, it contributes to the creation of communication environments characterized by patience, understanding, and empathy. In a world inundated with information and noise, these sessions stand as beacons, guiding individuals toward a more intentional and harmonious approach to interpersonal connection. For more information about my coaching check the link below.
linktr.ee/Dr_charrat_mohammed_ro...

The Conqueror of Worlds

Years ago, the biggest ape heard of a conqueror who carved a great empire out of an entire planet. - "It's only a legend" some people would say, "no such man could ever exist". Others would believe in his existence but not in his deeds: - "No such man could ever exist", they would also say. - "A blood-thirsty, thug" said one intellectual. "It's a good thing we no longer have to deal with such people." - "When he died", he continued, "His last command was to be buried at a secret place, and anyone who buried him murdered." -"Any indications as to that place?", asked the biggest ape. -"Nothing making sense.", said the intellectual. "He is said to be buried at the threshold. Where the mountain, meets the sea. Halfway between man and beast. Only where the eternal sun shines. To get there you would have to close your eyes and follow a narrow path by the moonlight. When the sun rises, you would see if you followed the right path. Then with everything revealed, you would face your Judgment". -"Hum.", grunted the biggest ape. Weeks later, the biggest ape was sitting at the burial place. Staring at the ancient tombstone in deep contemplation. *"May they doubt my deeds and that I ever walked amongst men, so only the worthy may believe"* Putting the dirt back on the stone, the biggest ape arose. "Rest, wise one." Thus spake Apathustra.

Don't Extinguish my Flame

*Authors : Tima EL & Khalil Z.* **In the enchanted realm of Celestria, where every soul possesses a mystical flame known as "Eclipsis," the sky dances with the collective radiance of its people. Amidst this luminous symphony, a shadowy force emerges—a darkness that hungers to shroud the brilliance of these magical flames.** Enter the Shadowvores, inhabitants of Celestria who are denied the embrace of Eclipsis. Instead, they bear formidable and robust bodies, enhancing their strength by absorbing and extinguishing the radiant Eclipsis flames of others. They embody the antithesis of Celestria, disrupting the delicate balance upheld by the natural ebb and flow of magical flames. With each extinguished Eclipsis flame, the once-vibrant light of Celestria wanes. At the heart of Celestria lies the Arcane Ember, the source of all Eclipsis flames. The people of Celestria engage in an eternal struggle against the Shadowvores, who crave this magical ember, bestowing absolute power upon its possessor. One fateful day, the Shadowweavers decide to launch a collective assault on the Celestrians, intent on seizing the Arcane Ember—the fount of unparalleled power. The consequence is grave: all the valiant inhabitants of Celestria succumb to the relentless onslaught. Remaining alone in Celestria, the Shadowvores start to vie for the coveted Arcane Ember. One Shadowweaver, thirsting for power driven by an insatiable hunger, stands before the radiant artifact, proclaiming,* "This is the flame I've been waiting for a long time."* The mystical ember responds with ancient wisdom, saying,* "And I, too, have awaited your presence for a long time."* Perplexed, the Shadowvore questions,* "You've been waiting for me?"* The Arcane Ember imparts a timeless truth,* "With every day's end, the night descends, and in the darkness, a promise lingers — after every night's embrace, the day invariably returns."* Determined to cast Celestria into eternal darkness, the Shadowvore retorts,* "The night in Celestria will never dawn."* In a plea to preserve its luminance, the Arcane Ember urges,* "Don't extinguish my flame."* Undeterred, the Shadowvore declares, *"You are the last beacon of light in my darkness. My strength won't reach its zenith if I don't extinguish you."* The Arcane Ember, embodying the essence of duality, counters, *" Do you think your strength will have meaning after extinguishing me?"* Undeterred by the wisdom offered, the Shadowvore remains steadfast in their resolve. *"I care not for the meaning of strength. I crave power, dominance, and the eternal night that shall reign over Celestria,"* they declare with an ominous intensity. The Arcane Ember's voice resonates with a potent echo,* "In your pursuit of power, you risk losing the very foundation of existence. Celestria thrives on the delicate dance between opposites. Darkness needs light, just as strength needs meaning. Without balance, your power becomes an empty void. Let the day dawn again."* A profound silence envelops the realm of Celestria as the clash between light and darkness reaches its zenith, echoing through the magical tapestry of this enchanted world.... Note : "The link below contains the image that is the source of inspiration for writing this short story :) "
drive.google.com/file/d/1UMTqnOD...

French Expedition of Larache 1765 , Tale of a Moroccan Victory

The Seven Years' war has just ended in 1763, considered to be the real 1st world war. It was a deadly and costly war that left all belligerents heavily in debt. For instance this was the main reason that lead to the American War of Independence. During this war, Moroccan pirates harassed French ships, not hesitating to attack merchant ships and lonely warships. The King of France Louis XV tried to buy peace from the Moroccan sultan Mohammed III but faced with failure in negotiations, he decided to launch a punitive expedition against the sultan. He charged the chef d'escadre du Chaffault with this expedition. Du Chaffault set sail in 1765 for the Moroccan coasts at the head of a squadron composed of 16 ships. Count De Grasse, another famous figure, was also in the party. During their journey, they surprised Moroccan pirates hiding at the mouth of the Loukkous river, they managed to destroy a brigantine and 2 other ships that the corsairs had captured the day before using a xebec. The latter managed to take refuge in Larache. The squadron arrived at Salé and began to bombard it. The Moroccans responded with heavy fire using 9 batteries, 4 in Salé-le-Vieux and 5 in Salé-le-Neuf(Rabat). The French had the technological edge, but the Moroccan steady fire prevented the french guns from being accurate. The French abandoned the idea of ​​entering the river alerted, by a nearby Swedish ship, that the Moors are in numbers and on the lookout. The King of Morocco, and his guard was also present in Rabat. Furthermore, the mouth of Bouregreg is narrow and presents an ambush risk. Du Chaffault then decides to find a Moroccan port that is easier to punish. They left for Mamora (Mehdia) but the bad weather and the presence of only one small ship in the river was not enough for the French. They decided afterwards to leave for Larache. During their misty journey, they came face to face with a Senau (img) of Swedish origin, previously captured by the privateers, which was on his way to resupply Salé with ammunition. After his capture Du chaffault sent it to Brest under good escort. In front of Larache, they saw La Sirene, a large French merchant ship taken by the Moors at Cadiz in 1764. The temptation to burn this prize was irresistible. Using a diversionary tactic, they tried to go straight to burn La Sirene but the swell prevented them from doing so. In the meantime, French ships' artillery was able to silence the batteries of Larache citadel. The citadel was built by the Portuguese in order to resist land attacks and not sea ones. Using their longboat, the French launched a 2nd and a 3rd expedition to burn Moroccan ships but with no success. They decided to launch a 4th attack, deeper this time. But the Moroccans had prepared a ruse. They left few ships near the port as baits. They deployed their skirmishers in well hidden positions on both sides of the shore. As the French longboats progressed, they were taken in enfilade by Moroccan fire. More than 4000 Moors surrounded the French and began to approach them. It was a massacre. Between 200 and 450 KIA on the French side. Many of those who tried to flee were drowned, very few managed to escape to their ships. The wounded one were finished with axes and their heads were cut off. The survivors were enslaved and sent to build Mogador(Essaouira). One of the survivors Bidé de Maurville would later write a book: "Relation de l'affaire de Larache". France will later pay a heavy price for the release of the captives. The French navy was humiliated a second time after the Seven Years' War.
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AN INTERNATIONAL CONFERENCE ON PHENYLKETONURIA IN MOROCCO

The 2nd international conference on phenylketonuria (PKU) was held on November 17-19, 2023, in Marrakech. This event was co-organized by 4 associations: The Moroccan Association for Child and Mother’s Health (AMSEM), HMEMSA (Home of Moroccan Educators and Moroccan Students in America), SOS PKU MAROC, American Moroccan Competencies Network, and the support of the Alliance of Rare Diseases in Morocco (AMRM). INFORMATION AND AWARENESS FOR HEALTH PROFESSIONALS AS WELL AS PATIENTS AND FAMILIES This event aimed to promote the health of affected people with this disease through education, awareness, and support for research. PKU is a rare hereditary disease responsible, in the absence of diagnosis and early treatment, for psychomotor and mental retardation with serious consequences. The accumulation of an aminoacid (phenylalanine) becomes toxic and destroys the nerve cells in the brain. The only available treatment is a diet based on dietary products with low amounts of phenylalanine, which are, unfortunately, very expensive. Eminent specialists from Morocco, the United States, Canada, and Europe intervened during the first scientific day. The 2nd day “PKU family camp” was dedicated to families, patients, and medical professionals to exchange the right support for parents with PKU patients and the long-life management of these patients. The day will was also an opportunity for the clinician specialists to offer consultations to patients and psycho-educational support to their families. AN AFFLICTION WITH TOO OFTEN IRREVERSIBLE CONSEQUENCES PKU is caused by a disorder in the metabolism of phenylalanine, an aminoacid (protein fragment) present in food, and typically transformed into another aminoacid, tyrosine. The enzyme responsible for this aminoacid conversion is defective in PKU patients. The PKU babies gradually develop mental and psychomotor retardation with symptoms such as seizures, nausea and vomiting, skin rash, hyperactivity, aggression or self-harm, reduced head circumference (microcephaly), lighter skin, eyes and hair (a result of tyrosine deficiency). Children often have a “mousy” or musty odor due to a phenylalanine by product in their urine and sweat. THE DIET IS “AN ALMOST IMPOSSIBLE MISSION.” The child must follow a very strict low-protein diet, where meat, fish, eggs, dairy products, and starchy foods are eliminated until the age of 12, then, depending on the case, relaxed during adolescence. The precarious availability in Morocco and the high cost of specific dietary products (flour, special pasta, complementary solutions, etc.) often mean that children “literally starve” to respect these rules. A box of specific milk for children costs around 500 Dh and is rarely available in Morocco! In addition, a medication that stimulates the breakdown of phenylalanine and helps reduce the diet in some children exists but is also unavailable! In addition to the enormous constraints generated by the disease, families experience a “real struggle” between the high cost and unavailability of treatment! We must underline the significant assistance the association HEMSA in the US provided for shipping dietary products to SOS PKU in Morocco and their continuous advocacy efforts to have PKU recognized in Morocco. A LIFE-SAVING GESTURE BUT UNFORTUNATELY NOT SYSTEMATIZED IN MOROCCO : NEONATAL SCREENING Depending on the country, the disease affects between 1 in 20,000 and 1 in 4,000 newborns. Morocco most likely has a high prevalence due to the high consanguinity in the society, which increases the frequency of this genetic disease. Typically, this disease must be screened systematically in all newborns; the absence of this screening and the early regime results in several thousand children and adults with mental disabilities. This test, carried out using a few drops of blood taken on the 3rd day of life and placed on a blotting paper, would make it possible to avoid these complications. The test already exists in all European and certain Arab countries. CONSULTATION WITH PUBLIC AUTHORITIES Discussions are underway with the Ministry of Health and the various stakeholders for recognizing PKU as a long-term condition, launching a neonatal screening program, and marketing dietary products in Morocco. The event was an an excellent opportunity to sign partnership agreements between AMSEM and SOS PKU MAROC with the Alliance of Rare Diseases in Morocco. This exciting development will undoubtedly pave the way for fruitful collaboration between these organizations, improve and save lives, reduce PKU patients suffering, and provide substantial spill over benefits for maternal, child, and family health. Dr MOUSSAYER KHADIJA الدكتورة خديجة موسيار Chairwoman of Alliance Rare diseases Morocco RESUME EN FRANÇAIS Les 17 et 18 novembre 2023 s’est tenue à Marrakech la 2ème conférence internationale sur la phénylcétonurie (PCU), coorganisée par 4 entités : Association Marocaine pour la Santé de l’Enfant et de la Mère (AMSEM), HMEMSA (Home of Moroccan Educators and Moroccan Students in America), SOS PKU MAROC, American Moroccan Competencies Network et avec le soutien de l’Alliance des Maladies Rares au Maroc (AMRM). Cet évènement avait pour objectif de promouvoir la santé des personnes atteinte à travers l’éducation, la sensibilisation et le soutien à la recherche. La PCU est une maladie rare héréditaire responsable, en absence de diagnostic et de prise en charge précoce, d’un retard psychomoteur et mental aux conséquences graves, à la suite de la destruction des cellules nerveuses du cerveau par l’accumulation toxique d’un acide aminé (phénylalanine). Le seul traitement est un régime alimentaire se basant sur des produits diététiques faibles en phénylalanine, malheureusement très chers. D’éminents spécialistes du Maroc, des Etats Unis, du Canada et d’Europe sont intervenus lors d’une 1ère journée scientifique. La 2ème journée, le « PKU family camp », a été dédiée aux familles, patients et aussi au corps médical pour échanger et faire connaître les bonnes pratiques au quotidien, notamment pour une meilleure efficience du régime.

From 'Yikes!' to 'Yes, Please!': Snake Venom's Medical Magic

Think of snake venom as nature's spicy sauce – it's not just for biting! Each snake mixes its own special blend, some zapping nerves (neurotoxic) and others messing with blood (hemotoxic). But here's the fun twist: this scary snake juice is stirring up some medical magic. Got high blood pressure? Thank pit vipers for Captopril. Clotty blood? Tip your hat to the tiny pygmy rattlesnake for Eptifibatide. Who knew snake venom could go from 'Yikes!' to 'Yes, please!' in the world of medicine?

The Misadventures of a Helpful Bionic Arm

Once there was a man with a bionic arm that had a mind of its own. One day, while dining in a fancy restaurant, his bionic arm suddenly decided to help. It began pouring water, but missed the glass, showering a nearby cat instead. The cat, startled, leaped onto the chandelier. The man, embarrassed, tried to control his arm, but it enthusiastically started serving bread to everyone, including a bewildered dog outside. The chaos ended with a round of applause from the amused diners and a very proud bionic arm, convinced it was the best waiter ever.

The adventures of Billy (part 1)

Billy liked driving his car To see his friends who lived afar Billy's driving wasn't intricate He never forgot to indicate Except sometimes at roundabouts His indicator would mess about And so did Billy wonder Was it for worse or for better That he should think less But to endure the stress Of never knowing which Turn would make it glitch And so did billy wonder And so did billy wonder

The Ideal

As the biggest ape was at his desk, a small child approached him. He was tiny, much smaller than children his age with clear, sparkling eyes. -"What are you doing", said the child. -"I am writing a book", said the biggest ape. -"About what?" -"The ideal." The child paused a minute, thinking. -"Are you the ideal?" -"No." -"Have you seen it?" -"No." "Then how can you write about something you don't know?" The biggest paused and laughed. -"That is the nature of the ideal.", said the biggest ape. "It can always be perceived, but never seen. When you call upon it, it comes. Never fully, never for long. When you've been touched by it, it is your duty to keep some of it's sent about you." Turning towards the child he added. -"This is how you call the ideal: you think about it, you perceive it and you write about it. So others as well might be touched by it". -"I understand." Thus spake the child.

Four keys to create supervised learning model

Supervised learning is a strategy in machine learning that enables a model to learn from data without being explicitly programmed. In other words, in supervised learning, the model tries to find the relationship between the "input" X and the "output" Y. Therefore, the first key to creating a supervised learning model is the dataset. **Key 1 : Dataset** Having a labeled dataset is essential, including two important types of information: the target variable Y, which is what we want to predict, and the explanatory variable X, which are the factors that help us make predictions. Let's take an example: imagine we want our model to predict the weather (Y) based on factors like temperature, humidity, and wind speed (X). To do this, we gather a dataset with information from the past, where we already know both the weather outcomes (Y) and the corresponding factors (X). This dataset acts like a box of puzzle pieces. Each piece represents one of the factors, and finding the relationship between these pieces defines the weather. We can represent this relationship as a mathematical equation, like this: Y = F(X), where F represents our model. Therefore, the second key is the Model. **Key 2: Model** The fundamental model in supervised machine learning is a linear model expressed as y = ax + b. However, the real world often presents nonlinear problems. In such cases, we explore non-linear models, such as a polynomial of degree two like y = ax² + bx + c, or even of degree three, and beyond. It's crucial to understand that each model has parameters requiring adjustment during training. Consequently, the two remaining critical components are the cost function and the optimization algorithm. **Key 3 : Cost Function** In machine learning, a cost function, also called a loss or objective function, quantifies the gap between the target and predicted values, signifying the model's error. The aim is to minimize this error to craft the most effective model. **Key 4 : Optimizer** Optimizer forms the core of a machine learning model, representing the strategy to discover parameter values that minimize the cost function. It plays a crucial role in fine-tuning the model for optimal performance.

Part 5/5: PhD - The Eternal Optimist: Next Time Will Be Different (But Not Really)

PhD Students: Where Schedules are Fiction and Coffee is King! "Colorful Calendars, Doomed to Fail": PhD students craft rainbow schedules, thinking this time it'll stick. Spoiler: It doesn't. "Surprise! More Work": Just when they think they've got it sorted, in swoops an email with a 'fun' new task. So long, free time! "Becoming a Night Creature": Who needs sunlight? The real magic happens at 2 AM, fueled by the glow of a laptop screen. "Coffee: The New Water": PhD students don't just drink coffee; they breathe it. It's not a choice; it's survival. "Procrastination Olympics": Watch as they masterfully avoid work by reorganizing sock drawers. Followed by panic-induced hyper-productivity. "Time, What's That?": One minute it's Monday; next, it's deadline day. Time flies when you're... panicking. "Free Time? Sounds Fake": When they do get a break, they're too puzzled to enjoy it. Ends up napping with books as pillows. "Deadline Superhero Mode": Everything gets done in a last-minute frenzy. How? Magic (and maybe a bit of crying). "Post-Deadline Amnesia": Once it's over, they forget the chaos and swear to never repeat it. Narrator: "They will." "Next Time Will Be Different": The eternal PhD mantra. Hope springs eternal, but so does the chaos. Basically, PhD students are like superheroes who fight the villains of procrastination and deadlines with the power of caffeine and last-minute panic. "Running on coffee and a questionable understanding of time management!"

Melusine - Part 1

The sun, that day, had forgotten to set. As he was reclining on a curvy and narrow chaise longue, Sebastian Byrne looked at the slant rays glimmering through the yellowing leaves on the lowest branches of the elms. Their brass-trimmed green lace ebbed and flowed as the wind blew away the last minutes of the golden hour. Sebastian brought the quilt closer to his neck. He sighed, scattering some crumbs around for the birds; but that evening none dared to fly by. Maybe Nathan had lost track of time on his way to the post office and back, and would not come, as he promised, before dusk. They had always watched the sun set together. They did so for the last six weeks, before Sebastian fell ill; and for the first day he could step outside, Nathan did not even bother to be on time. Undergrads will be undergrads… Sebastian was staring absentmindedly at the slow, suspended vanishing of the light when muffled footsteps echoed down the hill, along the side path that lead to the verandah. - Sebastian! The silvery voice rushed towards Sebastian, followed from a distance by a buoyant, youthful figure clad in light linen, waving a folded paper. The figure flew nearer, leaping, kid-like, on the smooth slope where Mrs Byrne’s garden weaved itself into a wilderness of low bushes and wild roses. A smile flickered across Sebastian’s thin, slightly parched lips, and disappeared. He had always seen Nathan skipping and leaping around, from the day he had interviewed him as a candidate for Oxford. While most of the applicants were timidly sliming along the college’s staircases and the tutors’ questions, Nathan jumped along the steps as he did through Greek and Latin periods. A rare breed he was, that seventeen-year-old brat, in a time when undergraduate faces were drawn by sullenness and tedious ploughing. And here he was, two years later, running back from Mrs Byrne’s country house, a letter in his hand. It was that white rectangle that chased Sebastian’s smile away. It was, doubtlessly, the answer Nathan had been expecting for weeks. Sebastian, they wrote back! « I know », thought Sebastian. « They wrote back and had the answer been negative, you would not have leaped so vivaciously, would you now? » Presently Nathan threw himself on the chaise longue, which squeaked under the attack, and stuck the letter under Sebastian’s nose. - Tolle, lege! Sebastian’s lips quivered as he caught glimpses of the words carefully drawn in dense black ink on the white paper. The handwriting leaned gently towards the right, on even lines that left an elegant margin on each side of the silken-white paper. Dear Sir, I am very grateful for you reply. I have read the reference letter sent to me by Doctor Byrne with great interest and his account of your accomplishments… We are very pleased that you are able to join us in spite of the circumstances… Looking forward… Did Madame de La S*** answer herself? Sebastian did not read any further. The thin, straight lines seemed to curl up, fading into one another, becoming barely legible. He smiled and extended his hand: « Well done, young man. This is an unexpected step, but an expected success. And they seem quite keen. » The last paragraph was indeed pressuring. It was urgent that the position would be filled. As many other applicants had manifested interest, Nathan was expected to arrive as early as possible, or they will be forced to hire someone else. « I would need to go as early as possible, maybe the day after tomorrow », said Nathan. It was not until then that Nathan looked at his tutor’s face. As the golden sunlight was turning to purple, he realized the sudden and deep changes the disease had impressed on Sebastian Byrne’s face, once full of strength, intelligence, and mercy. When he had first met Sebastian — then Doctor Byrne to him, Nathaniel Kiernan fell under the spell of these grey eyes, so deeply grey they sometimes seemed black. For two years, almost every day, he had sat under their keen gaze in Sebastian’s room, a shabby but spacious set that overlooked Saint Mary’s tower and the Bodleian’s dome. Those were the days we shall remember as the last golden golden glory sining over the Spires. Not that these were better days, but this time is gone. Surely, then, tutors complained about the termly fifth)week gloom, about the food, at times too rich and at times too poor, and about the noises that the new automobiles made, covering the trodding and rattling of the carriages. Those days poured over the city one after the other, year after year. Matriculation speech faded into Christmas carols as we snuggled in library nooks during the winter; then Summer Eights dragged us out by the river, revision books in hand, then graduation ceremonies rushed upon us and after the long, and yet too short, summer vacation, Matriculation happened again, ushering in a new cohort of Freshers’ faces, at once enthusiastic and anxious, the youthful barbarians from Eton or Harrow, the models of appropriateness from hard-working grammar schools. Under the gaze of the dreaming spires, the streets teemed with laughter that rang along the chiming bells, with inebriated songs at the crack of dawn, with the joyful glee and careless wrath that came with the examinations’ results. While the colleges remained unchanged, their stones and statues clad in centuries of iteration, the young faces around made every morning new. Even Sir Rayleigh, the provost, seemed like a playful young man to Nathan the first time he met him, his eyes sparkling with cheerful wit under his wrinkled forehead and his snow-white hair. Nathan was one of these modern foundlings, all family ties loosened by a scandalous divorce that threw the name he bore into shame, then into oblivion. Her mother at least had the decency to spare enough money for his education but just enough. Her family would refuse to do anything for a Kiernan boy. As he settled in Oxford, Nathan saw Doctor Byrne as a master more than a tutor. He was impressed by the man’s thoughtful silences as much as by his constant good spirits; he mimicked the way Byrne’s long white fingers rose in a slow arabesque before he spoke, strived to reform the sharp angles of his character to match Byrne’s composed temperance, and copied Byrne’s way of parting his hair in a falsely messy line he wore slightly askew. « Byrne has his way with the young gentlemen, the provost used to say. He talks to them like he was their father, and smiles at them like he was their sister! ». What a difference a few months had made. Oxford, in a few days, was deserted as people ran away from a nameless disease, that seemed to appear nowhere else.

The nomad developer setup #2: infrastructure as code

In a first article, I shared a quick and easy way to access VScode from any browser. You still need to create a cloud provider account and setup a server. In this second article I will share with you a way to automate all the steps needed from the moment you have created your account to using VScode in the browser. In order to do this I am sharing a GitHub repo at the end of this article. It contains all the Infrastructure as Code (IaC) you need. IaC is a practice in software engineering, mostly on the devops side, that involves managing and provisioning infrastructure through code, rather than manual processes. It allows for the automated deployment and configuration of infrastructure, enabling consistency, scalability, and version control for your infrastructure. The repository combines three very powerful tools: Packer, Ansible and Terraform. - Packer is a tool to create machine images avoiding to re-install everything every time you start an instance. - Ansible is an automation tool that simplifies complex tasks like configuration management. In a simple yaml file (a playbook) you can install and configure your server(s). - Terraform is an infrastructure as code tool that enables the provisioning and management of cloud resources using declarative configuration files. Please check the README carefully, it lists the current limitations and will be updated when the repo evolves. In a next article I will add even more automation to it using a ci/cd (continuous integration and continuous delivery) pipeline using GitHub workflow to allow you to start/stop this infrastructure as you wish without accessing anything else than a web browser. Happy Devops!
github.com/azieger/remote-workst...

The Gates of Hell

Many days and many nights did the biggest ape spend on this strange planet. The planet of moral people who talk often of hell. They had a dress for man, one for married women, one for boys, one for girls. When the priests called to prayers they came, when the priests called to sacrifice they sacrificed. They all woke up at the same time, ate a same time, prayed at the same time. Their lives ruled by a religion under the rhythm of the stars. -"We do it for this is good", said some. -"We do it because it's best", said others. Never did the biggest ape enquire further for he knew they had no more explanation to give. One day at the market he met a learned man of those people. "We do it because our fathers did it, and before them our forefathers", said the old man, his voice as dry and leathery as his skin. "Obedience was the primary virtue of our forefathers and what brought them glory and paradise". He paused for a while, appearing to think. "We are nowhere as obedient as they were and for that we suffer, this is the reason for our poverty and wretchedness." And with that the old man raised his eyes, deeply sunken in dark caves, hidden behind the weight of eyebrows too big for the emaciated face. The biggest ape rose and took his leave, he had nothing to say. As he was making his way out, a man stood in front of him, unmoved by the lamentations, unstirred by the calls of the priests. There he stood behind his stole. -"Who is this man?", asked the biggest ape. -"He is the richest merchant. ", said one. -"We buy from him because he cheats less", said another, "if only he was more moral like us". -"If only he would pray like us", lamented a woman. -"If only he would give some of his money", said a beggar. -"It pains us that he should go to hell", whispered and old woman. Hearing the talk the man looked up, locking eyes with the biggest ape. 'If I ever enter a god's hell', said the man, 'I will make sure to do so an a honest man.' 'I understand'. Thus thought Apathustra.

Part 4/5: Research, Rants, & Ridiculousness: The Lighter Side of PhD Madness

PhD: the art of turning coffee, chaos, and code into a degree, one panic attack at a time. - My machine learning model predicted I'd finish my PhD on time. Spoiler: Even AI has a sense of humor. - Neurotoxicity research: figuring out if it's the toxins affecting the brain, or just the endless hours in the lab. - Snake venom for drug discovery? Sure, because handling deadly snakes is less frightening than asking my advisor for a deadline extension. - I told my computer to find a cure for snake bites. It opened a travel site to Antarctica. No snakes, no bites, problem solved!

Morocco, Spain, and Portugal World Cup 2030: An Unforgettable Cultural Experience

The 2030 World Cup organization by Morocco, Spain, and Portugal can be analyzed using various approaches. In this article, I want to open a path for an anthropological and cultural analysis of this subject. Morocco, Spain, and Portugal's joint bid for hosting the FIFA World Cup in 2030 has been recognized as a historic decision. The triumph is a significant event for these three nations, as it marks the first time they have worked together to showcase their unique cultural heritage, stunning landscapes, and passion for football on the global stage. The spirit of cooperation and unity among these diverse nations is reflected in this collaborative effort, which embodies not just football passion but also the spirit of cooperation and unity. Football's capacity to bridge borders and foster international friendships can be reflected by hosting the tournament jointly. Combining the vibrant culture of the kingdom of Morocco with the rich traditions of Spain and Portugal, the World Cup 2030 will offer an immersive fusion of flavors, music, and festivities. Morocco gives guests the opportunity to encounter the charming climate of the dynamic medinas, investigate the noteworthy engineering of cities such as Marrakech and Fez "Founded under Idrisid rule during the 8th–9th centuries CE," and enjoy within the country's delightful food. Fans will pick up a more profound understanding and appreciation of Morocco's social traditions through witnessing traditional music and dance performances. Spain, on the other hand, brags a captivating blend of old-world charm and present day dynamic quality.Whether it's exploring the antiquated lanes of Barcelona, seeing the emotional flamenco exhibitions of Andalusia, or indulging in mouth-watering tapas and paella, fans will be inundated within the wealthy cultural tapestry that Spain should offer. Portugal, known for its pleasant scenes, noteworthy cities, and warm neighborliness, includes another layer of social differing qualities to the World cup 2030 experience. Guests can meander through the cobbled roads of Lisbon, visit medieval castles in Sintra, and taste the popular Harbour wine in Porto. The captivating sounds of traditional Fado music, filled with feeling and energy, will transport fans into the soul of Portuguese culture. All three nations have a profound cherish for football, and it is interlaced into their social texture. The World Cup 2030 will be an opportunity for fans to witness firsthand the passion and fervor that football brings to these countries. From exuberant road celebrations to colorful pre-match customs, each viewpoint of the competition will be implanted with the social traditions of Morocco, Spain, and Portugal. The joint bid of Morocco, Spain, and Portugal winning the organization of the World cup 2030 guarantees a genuinely exceptional social involvement for everybody included. From investigating noteworthy cities and reveling in nearby cuisines to drenching oneself within the traditions and music of each nation, the competition will be a celebration of social differing qualities and solidarity. Football fans from around the world can see forward to not as it were seeing top-class matches but moreover being portion of an immersive social travel that will take off enduring memories

Part 3/5: 9 Hilarious Truths Only Ph.D. Students Will Understand

Ph.D. Life: When Your Brain Expands, and Your Social Life Disappears! - Coffee Transformation: You start to believe that coffee is a basic human right. - Time Bender: Somehow, all your deadlines are 'tomorrow'. - Lab Maze Runner: You know your lab better than your own home. - Conference Life: You're there for the free coffee and snacks. - Email Excavation: Finding an old email feels like a treasure hunt. - PDF Collector: You have more unread academic papers than unread emails. - Thesis Magic: Turning random experiments into a thesis feels like a magic trick. - Jargon Juggler: You speak a strange language that only five people in the world understand. - Nap Ninja: Mastering the art of napping anywhere, anytime.

"Supervised and Unsupervised Learning in 90 Seconds of Reading"

** Brief Definition : ** Supervised and unsupervised learning are two fundamental facets of machine learning, each specifically tailored to handle distinct types of data. In supervised learning, the machine learning algorithm is trained on a labeled dataset, where each data point consists of both input features and corresponding output labels. The goal is for the algorithm to learn the mapping from inputs to outputs based on these labeled examples. In unsupervised learning, the machine learning algorithm is trained on an unlabeled dataset to find hidden patterns, structures, or relationships within the data. Unlike supervised learning, there are no predefined output labels for the algorithm to learn from. ** Intuition 🙂 : ** In supervised learning, envision having a jigsaw puzzle featuring a picture of a dog, where each puzzle piece is labeled with its correct position in the completed picture. The model learns from these labeled examples, figuring out the relationships between the shapes and colors of the pieces and their correct locations.This process, often referred to as the training step, allows the model to internalize the patterns within the labeled data. Subsequently, after training, the model is adept at taking a new puzzle of a dog and precisely assembling it based on the knowledge acquired during the training process. Now, imagine you have a bag of puzzle pieces without a picture or labels — just a mix of colors and shapes. In unsupervised learning, the model explores the characteristics of the puzzle pieces without any predefined labels or information about the complete picture, identifying groups that share similar colors, shapes, or patterns. The model doesn't know what the complete picture looks like, but it discovers that certain pieces belong together based on shared features. These groups represent clusters of similar puzzle pieces. In this puzzle analogy, supervised learning entails constructing a model with labeled examples to tackle a specific task, while unsupervised learning involves the model autonomously uncovering patterns or relationships within the data without explicit direction.

Rock Lined Pockets

See the alarm in the shark’s cadence, Hear the sharp seagull’s cry: The merling king has come! The merling king has come! Jellyfish floating around his cloudy crystal crown Like translucent passive thoughts of aggression. Will he forgive your primate indiscretion? In his court of slime and rock sublime He beckons you with open tentacles to join his circle of hedonistic companions. The mermaid is a murderous creature. The dolphins are wanton and wild. What’s that in your pockets? The inquisitive mollusk asks. Rocks. Of the precious kind? No. His soft limbs curl back in plain disappointment. From under a shell a faint voice cautioned, Do not trust in the soft bodied rogue’s trade. Down here the written word is as fleeting as the spoken one.

Part 2/5: Humor in the Halls of Academia: A Light-Hearted Look at PhD Life

Here are some humorous and light-hearted "PhD" abbreviations: - Permanently head Damaged (PhD): A playful nod to the intense intellectual effort involved in earning a PhD. - Piled higher and Deeper (PhD): A humorous take on the depth and complexity of PhD-level research. - Patiently hoping for a Degree (PhD): Reflects the long and often uncertain journey towards completing a PhD. - Probably half Delirious (PhD): Acknowledges the stress and mental strain that can come with pursuing a doctorate. - Pizza hut Delivery (PhD): A fun twist, imagining a PhD as something entirely different. - Project half Done (PhD): For those times when it feels like the thesis will never be completed. - Philosophically Disturbed (PhD): A witty take on the deep and often complex thinking required for a PhD. These are meant in good humor and to bring a light-hearted perspective to the serious and commendable pursuit of a PhD.

Part 1/5: Why You Should Apply for a PhD Regardless of Your Background

Less than 2% of the world's population holds a doctorate degree. Do you aspire to be part of the average, or will you strive to join the ranks of these distinguished individuals? - Expanding Knowledge: Deepen expertise in your chosen field, enhancing critical thinking and problem-solving skills. Gain unparalleled understanding and push the boundaries of what's known. - Personal Growth: Develop resilience, independence, and management skills through challenging research projects. Cultivate self-discipline and adaptability, crucial for success in any endeavor. - Career Opportunities: Opens doors to advanced roles in academia (research, teaching) and industry (R&D, consultancy, management). Elevates your professional profile and broadens career prospects. - Networking: Connect with professionals and academics for future collaborations and career advancement. Build a valuable network of contacts that can support your career for years to come. - Contribution to Field: Make significant contributions to your field, influencing both academic research and industry practices. Your work could lead to new discoveries, innovations, or methodologies. - Inclusivity and Diversity: Encourages a mix of perspectives, challenging stereotypes and promoting inclusivity in academia and industry. Contributes to a more diverse and equitable professional landscape. - Professional and Personal Transformation: A PhD is a journey of both professional expertise and personal development, beneficial for all backgrounds. It's an opportunity to grow intellectually, professionally, and personally. - Leadership Skills: Develop leadership abilities by guiding research projects, mentoring students, and collaborating with various stakeholders. - Global Perspective: Gain exposure to international research communities, broadening your understanding of global challenges and solutions. - Recognition and Prestige: Achieve a level of recognition and prestige in your field, establishing yourself as an authority and thought leader.

"Understanding Overfitting and Underfitting in a Quick 90-Second Read"

Overfitting and underfitting represent two common issues in machine learning that affect the performance of a model. In the context of overfitting, the model learns the training data too precisely, capturing noise and fluctuations that are specific to the training set but do not generalize well to new, unseen data. Underfitting, on the other hand, occurs when a model is enabled to capture the underlying patterns in the training data, resulting in poor performance not only on the training set but also on new, unseen data. It indicates a failure to learn the complexities of the data. **Analogy : ** Intuitively, returning to the example of the student that we presented in the definition of the machine learning concept, we discussed the possibility of considering a machine learning model as a student in a class. After the lecture phase, equivalent to the training step for the model, the student takes an exam or quiz to confirm their understanding of the course material. Now, imagine a student who failed to comprehend anything during the course and did not prepare. On the exam day, this student, having failed to grasp the content, will struggle to answer and will receive a low grade; this represents the case of underfitting in machine learning. On the other hand, let's consider another student who, despite having a limited understanding of the course, mechanically memorized the content and exercises. During the exam, when faced with questions reformulated or presented in a new manner, this student, having learned without true comprehension, will also fail due to the inability to adapt, illustrating the case of overfitting in machine learning. This analogy between a machine learning model and a student highlights the insightful parallels of underfitting and overfitting. Just as a student can fail by not grasping the course or memorizing without true understanding, a model can suffer from underfitting if it's too simple to capture patterns or overfitting if it memorizes the training data too precisely. Striking the right balance between complexity and generalization is crucial for developing effective machine learning models adaptable to diverse and unknown data. In essence, this educational analogy emphasizes the delicate equilibrium required in the machine learning learning process.

Part 5/5: 8 Inspiring Quotes on Leadership from Visionary Minds

Quotes can inspire visionary thinking, apply them wisely, and you'll witness the changes they bring about. "A leader is one who knows the way, goes the way, and shows the way." - John C. Maxwell "Success is not final, failure is not fatal: It is the courage to continue that counts." - Winston Churchill "Lead from the back — and let others believe they are in front." - Nelson Mandela "If your actions inspire others to dream more, learn more, do more and become more, you are a leader." - John Quincy Adams "Management is doing things right; leadership is doing the right things." - Peter Drucker "Leadership is not about being in charge. It is about taking care of those in your charge." - Simon Sinek "A leader takes people where they want to go. A great leader takes people where they don't necessarily want to go, but ought to be." - Rosalynn Carter "Be the change that you wish to see in the world." - Mahatma Gandhi

Part 4/5: Understanding Personalities for Leadership in Academia and Industry

Know yourself, understand others, and watch life's opportunities unfold. - Recognize Individual Differences: Acknowledge and appreciate the diverse personality types within your team, understanding how these differences can contribute to a rich, dynamic work environment in both academia and industry. - Adapt Communication Styles: Tailor your communication to suit various personality types. This includes being aware of how different people prefer to receive information and feedback. - Foster Inclusive Environments: Create a workplace culture that respects and values different personalities, encouraging open dialogue and collaboration in both academic and industrial settings. - Leverage Strengths: Identify and use the unique strengths of different personality types. In academia, this could mean assigning research roles based on individual strengths, while in industry, it might involve delegating tasks that align with team members' innate skills. - Manage Conflict Sensitively: Understand how different personalities might clash and develop strategies to manage conflicts effectively, keeping in mind the distinct environments of academia and industry. - Encourage Diverse Perspectives: Promote an environment where varied viewpoints are welcomed and considered. This is essential for fostering innovation and critical thinking in both fields. - Personalized Mentorship: Offer guidance and mentorship that resonates with the individual personalities of your team members, helping them grow and develop in their respective roles. - Embrace Learning Styles: Recognize that different personalities may prefer different learning styles. Adapt your teaching and training methods accordingly in both academic and industrial contexts. - Promote Self-Awareness: Encourage team members to understand their own personalities and how these impact their work and interactions. This self-awareness can lead to more effective collaboration and leadership. - Balance Team Dynamics: Strive for a balance of personalities in teams to ensure a harmonious and productive work environment. This involves understanding how different personalities can complement each other in both academia and industry.

Part 3/5: Observational Learning for Effective Leadership in Academia and Industry

Paying close attention to the details teaches you a lot! - Observe Leadership Styles: Focus on the behaviors and decision-making styles of leaders you admire in both academia and industry. Understand how they approach challenges and interact with their teams. - Learn from Mistakes: Pay attention to the errors made by others. Reflect on these mistakes and contemplate alternative solutions or approaches you would adopt in similar situations. - Seek Feedback: Consider feedback as a crucial learning tool. Use it to refine your strategies, communication, and leadership techniques. - Study Communication Methods: Analyze how leaders effectively communicate complex ideas in academic settings and practical solutions in industry. Notice the clarity, tone, and engagement tactics they use. - Understand Ethical Decision-Making: Observe how leaders handle ethical dilemmas, ensuring integrity and moral responsibility in both academic research and industry practices. - Adaptability to Contexts: Learn how leaders modify their approach when dealing with academic theories versus practical industry applications. Understand the nuances and requirements of each sector. - Collaboration and Team Dynamics: Watch how successful leaders foster teamwork and collaboration in both academia, where research projects often require interdisciplinary cooperation, and in industry, where cross-functional teamwork is key. - Innovative Problem-Solving: Notice how leaders in both fields use creativity and innovation to solve complex problems. See how academic theories can be applied in practical industry scenarios. - Mentorship and Development: Observe how leaders nurture talent and encourage growth in their teams, both in academic environments and in the workplace. - Continuous Learning and Adaptation: Recognize the importance of ongoing education and staying abreast of current trends and research in both academia and industry to inform effective leadership.

Part 2/5: The Power of Listening: A Key to Enhancing Your Leadership Skills

Listen more than you speak, and watch your world transform. - Building Trust and Respect: Leaders who actively listen to their team members cultivate an atmosphere of trust and respect. This approach demonstrates that the leader values their team's opinions and insights, fostering a more open and collaborative work environment. - Enhancing Decision-Making: Listening provides leaders with a broader perspective and more information, which is essential for informed decision-making. By understanding the viewpoints and concerns of their team, leaders can make decisions that are better aligned with the needs and goals of the organization. - Conflict Resolution: Effective listening is key in resolving conflicts. By listening to all sides of a disagreement, a leader can understand the underlying issues and work towards a solution that addresses the concerns of all parties involved. - Encouraging Innovation and Creativity: Leaders who listen are more likely to hear and encourage new ideas. This openness can foster an innovative culture where team members feel valued and motivated to contribute creatively. - Improving Team Dynamics: Listening helps leaders identify and address issues within the team, whether they are related to workflow, interpersonal relationships, or resource allocation. Addressing these issues promptly can lead to a more efficient and harmonious work environment. - Personal Growth and Learning: Leaders who are good listeners continuously learn from the people around them. This not only enhances their leadership skills but also keeps them connected to the latest trends, concerns, and opportunities within their organization. - Employee Motivation and Engagement: Employees feel more engaged and motivated when they know their voices are heard. This can lead to increased job satisfaction, lower turnover rates, and a more committed workforce. - Modeling Positive Behavior: When leaders demonstrate effective listening skills, they set a positive example for the entire organization. This can lead to a culture where everyone listens to each other, improving overall communication and collaboration.

Part 1/5 : Acquiring Self-Development and Leadership Skills: Beyond Innate Abilities

Becoming a great leader can transform your life, making you not only productive and satisfied but also widely admired. "The Power of Listening" - Practice active listening by giving full attention to the speaker. - Avoid interrupting and ask clarifying questions to show engagement. - Reflect on what is said and respond thoughtfully, demonstrating that you value their input. "Observational Learning" - Observe leaders you admire and note their behaviors and decision-making styles. - Learn from mistakes made by others, and think about how you would handle similar situations differently. "Navigating Team Dynamics" - Pay attention to the unique strengths and weaknesses of each team member. - Facilitate open and inclusive discussions to allow diverse perspectives to flourish. - Resolve conflicts by understanding the underlying issues and motivations. "Emotional Intelligence in Leadership" - Work on self-awareness to understand your emotions and how they affect others. - Practice empathy by putting yourself in your team members' shoes. - Develop your social skills, like effective communication and conflict resolution. "Understanding Personalities" - Study basic personality types and traits to better predict and understand behaviors. - Be adaptable in your approach to different personalities, customizing your leadership style as needed. - Show genuine interest in the personal and professional growth of your team members.

Grasping the concept of machine learning in just 90 seconds of reading

Machine learning is a branch of the artificial intelligence domain that encompasses various methods relying on learning from data to solve problems such as prediction, classification, dimensionality reduction, etc. Learning from the data means that machine learning systems can analyze patterns, extract insights, and make informed decisions without being explicitly programmed for a particular task. Instead of adhering to predetermined rules, machine learning methods adapt and improve their performance over time. The process involves training models, validating their accuracy, and testing their generalization to new, unseen data. Intuitively, we can envision the machine learning model as a student in a classroom. The teacher imparts knowledge to the student during what we refer to as the training step for the machine learning model. After the session, the student undergoes a quiz to solidify the concepts, representing the validation step for the machine learning model. Finally, the student takes a comprehensive final exam to test their understanding of the entire course. All of these stages occur gradually over what is termed as epochs in the context of a machine learning model. In this analogy, each epoch corresponds to a complete cycle of the training, validation, and testing phases. It's like the student attending multiple class sessions, quizzes, and exams to reinforce and assess their knowledge. With each successive epoch, the machine learning model refines its understanding of the data, enhancing its ability to make accurate predictions or classifications in real-world applications. Just as a student becomes more adept through repeated study sessions, the machine learning model becomes increasingly proficient with each pass through the data.

The Fool

One day the biggest ape was walking a lonely path leading to the top of a hill when he saw an emaciated man sitting below a dead tree. His clothes were in tatters and yet his eyes glew with the intensity of emptiness. "Strange", thought the biggest ape. - "Come", said the man as the biggest ape came closer to him. "I have news for you." "Let me tell you of the dreadful place called life", continued the old man. "Dreadful indeed it is, and full of sorrow, for life is suffering. I know for I have been cursed with intellect and discernment. I teach it for I hold compassion into my heart, and suffer for it dearly for I am but compassion. The truth. Happiness is the glow of the feeble minded, the madness of the blind. I know, I know, because..." -"Hum.", grunted the biggest ape without skipping a step. He was busy. At the top of the hill he heard a strange noise from behind and turned back. Instead of one old man, they were now many around the dead tree. All in tattered clothes, with glowing eyes looking at each other, backs turned to the world. "Let me tell you of the dreadful place called life..." he heard them say to each other. "Fools. I am busy." Thus spake Apathustra.