Think Forward.

L’étrange syndrome de l’odeur du poisson pourri 2454

Dr Moussayer khadija, 2 y.
- Science - Health -
3.4 min read.
Le syndrome de l’odeur du poisson pourri, appelé la triméthylaminurie, est un désordre métabolique rare où l’organisme est incapable de transformer une substance volatile mal odorante (la triméthylamine) en une autre sans odeur (oxyde de triméthylamine). Cette pathologie est connue en anglais sous le nom de Fish odor syndrome » (FOS) La triméthylamine (TMA) provient de certains aliments notamment les poissons de mer, les cacahuètes, les œufs et certains légumes. En l’absence de sa dégradation, elle s’accumule dans l'organisme et s’évapore par la sueur, l'urine et l'expiration, avec une forte odeur de poisson. LES CAUSES C’est une défaillance génétique de l’enzyme qui dégrade la TMA produite elle-même de la dégradation bactérienne intestinale d’aliments riches en ses précurseurs (choline, lécithine et carnitine). La TMA ainsi produite dans l’intestin sera rapidement transformée dans le foie et éliminée dans les urines sous forme d’oxyde de TMA. L’enzyme peut être totalement absente et la maladie s’exprime alors chez les enfants dès la diversification alimentaire. Si cette absence est partielle, les mauvaises odeurs sont intermittentes. Les personnes atteintes ont deux copies du gène défectueux . Les parents eux-mêmes peuvent n'avoir qu'une seule copie du gène défectueux et la pathologie sera transmise uniquement si les deux parents sont tous les deux porteurs d’une ou deux copies du gène défectueux ; ce qui signifie qu'une personne atteinte ne transmettra la maladie que si son partenaire est porteur. LES SIGNES Une odeur corporelle de poisson extrêmement désagréable que le corps dégage par la sueur, l’urine, la salive et l’haleine et même l’air expiré. L’intensité de cette odeur est variable d’une personne à l’autre et avec le temps. Ces symptômes difficiles à vivre peuvent entraîner un isolement, de l’anxiété et la dépression. On estime que plus de 200 personnes en seraient touchées dans le monde. LE TRAITEMENT DE CE SYNDROME Il n’existe actuellement aucun traitement curatif de la maladie. Les symptômes peuvent être fortement atténués par l’éviction de certains produits riches en TMA et ses précurseurs. Certains antibiotiques sont utiles en cures courtes pour réduire l’activité microbienne intestinale. Se laver fréquemment avec un savon acide et faire des exercices intenses avec sudation suivis par un lavage permet aussi une réduction des odeurs. Dr MOUSSAYER KHADIJA الدكتورة خديجة موسيار Spécialiste en médecine interne et en Gériatrie, Présidente de l’association marocaine des maladies auto-immunes et systémiques (AMMAIS), Présidente de l’Alliance Maladies Rares au Maroc (AMRM) اختصاصية في الطب الباطني و أمراض الشيخوخة رئيسة الجمعية المغربية لأمراض المناعة الذاتية و والجهازية , رئيسة ائتلاف الأمراض النادرة المغرب BIBLIOGRAPHIE - S. Nicolas and al, Le « Fish odor syndrome » : une maladie socialement invalidante - Fish odor syndrome : A socially disabling disorder, La Revue de Médecine Interne Volume 43, Issue 3, March 2022, Pages 178-180 https://doi.org/10.1016/j.revmed.2021.12.010 - Qu’est-ce que le syndrome de l’odeur du poisson ? Fréquence Médicale https://www.frequencemedicale.com/oncothoracique/patient/25623-Qu-est-ce-que-le-syndrome-de-l-odeur-du-poisson - Messenger J, Clark S, Massick S, Bechtel M. A review of trimethylaminuria: (fish odor syndrome). J Clin Aesthet Dermatol. 2013 Nov;6(11):45-8. PMID: 24307925; PMCID: PMC3848652. OVERVIEW Trimethylaminuria, or fish odor syndrome (FOS), is a condition characterized by the presence of trimethylamine (TMA)—a tertiary amine whose odor is described as resembling that of rotting fish—in the urine, sweat, and expired air. POUR EN SAVOIR PLUS, D’AUTRES EXEMPLES DE MALADIES TRES RARES On estime qu’une maladie est rare lorsqu’elle touche une faible fraction de la population. En Europe, le seuil est fixé à moins d’une personne sur 2 000. Certaines de ces pathologies ne peuvent concerner que quelques centaines de personnes dans le monde. Ainsi à titre d’exemple : Progéria La progéria, est une maladie génétique extrêmement rare qui accélère le vieillissement des nouveau-nés. Sa prévalence est exceptionnellement faible : 1 nouveau-né sur 7 000 000. Il n’y a pas de remède pour cette maladie génétique et la plupart des patients décèdent avant l’âge de 13 ans, atteignant exceptionnellement l’âge de 20 ans. Atrophie hémifaciale progressive Cette maladie affecte la peau, les muscles faciaux et les structures osseuses du visage. Elle n’implique généralement qu’un seul des plans de la tête (d’où son nom, hémifacial). L’atrophie unilatérale donne au patient un aspect très étrange, comme si la moitié de son visage était en train de se décomposer. Il n’y a pas de traitement pour cette affection, mais on emploie souvent la chirurgie esthétique pour en réduire le phénomène L'ostéogenèse imparfaite L’ostéogenèse imparfaite, ou maladie « des os de verre », est une affection génétique, caractérisée par une fragilité osseuse et une faible masse osseuse à l’origine de fractures à répétition, survenant à la suite de traumatismes bénins L'on compte environ un malade pour 10 000 à 20 000 personnes et elle ne peut donc être considérée comme "très rare" L’ostéogenèse imparfaite chez l'enfant ainsi que ces troubles annexes peuvent être traitées par différents traitements médicaux et chirurgicaux : traitement des fractures : en évitant les immobilisations trop rigides et trop prolongées, lutte contre la douleur des fractures du tassement vertébral par des médications ou par des contentions, apport régulier de vitamine D avec des ajouts de calcium si besoin… L’ALLIANCE DES MALADIES RARES AU MAROC (AMRM) Depuis sa création en 2017, l’ALLIANCE travaille au quotidien avec beaucoup d’associations marocaines spécifiques pour une maladie donnée. Elle a d'ailleurs déjà signé des conventions de partenariat « stratégiques » avec 12 associations de patients : 1/Association de syndrome de Rett (AMSR) , 2/ Association de Solidarité avec les Enfants de la Lune au Maroc (A.S.E.L.M.) , 3/ Association de l’amyotrophie spinale (SMA) , 4 / association SOS Pku , 5/ association marocaine des malades d’angioedème héréditaire (AMMAO) , 6/ Association Marocaine pour la Santé de l’Enfant et de la Mère (AMSEM) , 7/ Association S.O.S Marfantime (S.O.S.M.) , 8/Association Prader Willi Maroc (P.W.M.) , 9/ Association Flamme d'Espoir pour les Autistes et les Patients atteints de la PKU , 10/ Association marocaine pour les enfants souffrant d’ostéoporose (Ostéogenèse imparfaite) A.M.E.O.S , 11/ Association Marocaine de Mucoviscidose (AMM) , 12/ Association Fragile X Maroc (FxMa) . Au sein du bureau de l’Alliance, la présidente est entourée notamment du : Dr Fouzia Chraibi, ,Vice –Présidente , Dr Mounir Filali, Secrétaire général, M Mohammed Elaidi, Secrétaire général adjoint, Mme Najat Kababi, Trésorière et de Mme Fatima Lahouiry, Trésorière adjointe
Dr Moussayer khadija Dr Moussayer khadija

Dr Moussayer khadija

Dr MOUSSAYER KHADIJA الدكتورة خديجة موسيار Spécialiste en médecine interne et en Gériatrie en libéral à Casablanca. Présidente de l’Alliance Maladies Rares Maroc (AMRM) et de l’association marocaine des maladies auto-immunes et systémiques (AMMAIS), Vice-présidente du Groupe de l’Auto-Immunité Marocain (GEAIM)


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Agentic AI Beyond Benchmarks: Meta-Agents & the Future of AI Evaluation with Khalil Mrini 139

Tariq Daouda, 12 h.
I recently sat down with Khalil Mrini to talk about his work and international experiences. He has spent time in Marrakech, Switzerland, India, and the United States, each place influencing his perspective in different ways. We also mentioned his visit at the UM6P, his experience of the university, students and innkvative AI curriculum. Khalil presented his new paper on agentic AI. The paper focuses on the use of autonomous agents to evaluate and benchmark other agents: essentially, systems that can test one another’s capabilities. He described how this approach could provide a more dynamic and optimal method for measuring progress in AI research. We ended the conversation by discussing AI ethics. Our exchange raised open questions about responsibility, transparency, and how the field can ensure that increasingly autonomous systems align with human values.
youtu.be/zE7PKRjrid4

A Historical Triptych: How Morocco, Spain, and Portugal are Forging the Success of the 2030 World Cup 272

Imad Khater, 1 d.
The assignment of the 2030 FIFA World Cup hosting rights to the unprecedented trio of Morocco, Portugal, and Spain marks the opening of a new chapter in the history of international and sporting relations. The joint organization of this event confirms an unparalleled dynamic, engaging the three nations in a triangular cooperation whose efficiency will be the decisive marker of this global event's success. This trilateral partnership transcends mere logistical collaboration to become a true lever for strategic development. The question is no longer whether bilateral relations are ready, but how their integration into a strengthened trilateral framework will guarantee the success of a mega-event poised to connect, for the first time, two continents through the medium of sport. Historical ties and geographical proximity provide a fertile ground for a remarkable intensification of relations between these three partners. The announcement of their tripartite bid has, in fact, elevated the need for harmonized coordination in the logistical, economic, and security domains to the level of a strategic imperative. I. The Political and Economic Foundations of Enhanced Cooperation The alignment around the 2030 project is not fortuitous; it is rooted in deep political and economic considerations that mutualize the interests of the three countries. •⁠ ⁠The Imperative of Convergence suffers no ambivalence: Spain and Portugal, while operating within the structural framework of the European Union, recognize Morocco as an essential strategic partner, a genuine gateway and pivot to the African continent. This dynamic is not unilateral; the Kingdom is consolidating its Euro-African anchor with heightened clarity through this same alliance. The World Cup deadline, far from being a simple calendar constraint, acts as a powerful lever, forcing the acceleration—often judged too slow—of regulatory, customs, and security convergence processes among the three capitals. Crucially, the political will displayed at the highest level—symbolized by the direct monitoring of Moroccan commitments by His Majesty King Mohammed VI—stands as a decisive catalyst, ensuring the establishment of a unified and enduring policy line, even in the face of contingencies and fluctuations in political majorities within the allied states. •⁠ ⁠Mutualization of Investments and Benefits: On the economic front, the World Cup represents an unprecedented opportunity to boost trade and investment. The trilateral agreements directly influence the planning of major works: the goal is no longer to build isolated infrastructures, but integrated networks (ports, air links, potential high-speed rail connections) designed for interoperability. The harmonization of tourism offerings and incentivizing fiscal regimes for sponsors and investors is crucial to maximize shared benefits. The success of coordination in the logistical, economic, and security domains will not be merely a performance indicator; it will be the symbol of a collective capacity to manage a complex event on a transcontinental scale. II. Managing Complexities: The Challenges of Co-Development An event of this magnitude, operated by three sovereign states, naturally generates frictions and coordination challenges that require first-rate diplomatic and technical management. •⁠ ⁠The Challenge of Global Security and Integrated Transport: The primary obstacle is the creation of a unified security space for the millions of supporters on the move. This demands real-time information sharing, coordination of law enforcement agencies, and the harmonization of emergency protocols. Concurrently, the transport system must be conceived as a single network. The transit of teams and supporters between Europe and Africa must be fluid, reliable, and ecological, necessitating targeted investments in airport capacity and maritime services. •⁠ ⁠The Cultural and Civilizational Vector: Beyond sport, the World Cup is a diplomatic platform. The secondary, but fundamental, challenge is to move beyond simple technical organization to present an ideal model of intercultural coexistence. Morocco, Spain, and Portugal must invest in promoting their cross-cultural heritages, consolidating the values of peace and mutual respect. This involves qualifying national institutions not only in logistics but also in public management and global media interaction, to avoid the pitfalls of fragmented or sensationalist coverage. III. The Structuring Influence of Bilateral Agreements on Logistics The influence of existing agreements between the three countries is vital for infrastructure development. The current stage is characterized by high anticipation from the private sectors and sports observers, who are watching for the concrete acceleration of construction projects. The overall efficiency of the operation—whether considering the pre-event phase, execution during the tournament, or the post-realization legacy—rests entirely on the solidity of the triangular commitment. The transformation of infrastructures, from stadiums to training centers and reception areas, must be carried out in a spirit of normative alignment. In conclusion, the 2030 World Cup is not merely the sum of three national organizations; it is a project of strategic co-development. The strong historical relations uniting the Kingdom of Morocco, Portugal, and Spain, amplified by a constant and high-level political will, constitute the decisive element for transforming this bid into a resounding success, offering the world a precedent of successful integration between two shores.

Law 30-09: A “Tree with Bitter Fruits” Hindering the Development of Moroccan Sports 274

Imad Khater, 1 d.
- Politics - Society - Sports -
2.5 min read.
While Morocco’s recent performances on the international stage—particularly in football—demonstrate its growing dynamism, the legal framework governing the sports sector seems unable to keep pace with this evolution. Conceived in the wake of the 2008 Royal Letter and enacted in 2010, Law No. 30-09, which was meant to modernize the national sports system, now reveals—fifteen years after its delayed implementation—serious limitations. Marked by internal inconsistencies, deficient enforcement, and pervasive state interference, the law ultimately undermines its original purpose: to professionalize Moroccan sport and align it with international standards. I. Excessive Requirements and Forgotten Sanctions Born from a clear political will to reform Moroccan sport and provide it with a modern legal framework, Law 30-09 has quickly become a rigid and impractical instrument. One of its most emblematic—and controversial—provisions is the obligation imposed on certain sports associations to establish sports corporations (Sociétés Anonymes). While the intent was to ensure sound governance, fiscal transparency, and executive accountability, practice has revealed the limits of this approach. •⁠ ⁠A disproportionate constraint. Most associations lack the financial and organizational capacity to comply with such structural obligations. •⁠ ⁠A flawed and inapplicable framework. The law establishes three non-cumulative conditions triggering the obligation to form a sports company. Only the first has been clarified by regulation, while the other two—relating to turnover and payroll—were never defined by governmental decree. As a result, the rule remains largely inoperative, especially since the penalties for non-compliance are systematically ignored. •⁠ ⁠An unfinished reform. Even among the few clubs that have complied, the parent association still holds the majority of the share capital. This structural lock prevents the opening of capital to private investors, thus maintaining dependency on the old associative model rather than promoting professionalization. II. The Persistent Shadow of the State: An Interference Contrary to Autonomy Principles By its very nature, sport is a sphere of autonomy, an ethos enshrined in the Moroccan Constitution and in the regulations of international organizations such as FIFA. Yet Law 30-09 establishes the supervising ministry as the true guardian of the sector, concentrating significant and often excessive powers: •⁠ ⁠An extensive right of scrutiny. The ministry approves statutes, grants accreditation, and confers authorization to national federations. •⁠ ⁠A pronounced power of interference. The administration may impose standard contracts and, more seriously, revoke authorization or dissolve a federation in the event of a “serious violation.” Such prerogatives contradict the spirit of the Constitution, which reserves this power to the judiciary. •⁠ ⁠Institutional omnipresence. A state representative must sit within the governing bodies of both the national federations and the Moroccan National Olympic Committee (CNOM), reinforcing state oversight at the expense of autonomy. This predominant executive control contradicts the principles of independence that underpin both national constitutional law and the global sports governance model. III. The Ambiguous Status of Athletes: The Law’s Major Omission Beyond institutional deficiencies, Law 30-09 exposes a serious legal vacuum regarding the status of athletes. The professional athlete’s contract is treated as an ordinary employment contract—an assimilation that raises significant difficulties. •⁠ ⁠The legislator had to create several exceptions to the Labour Code (five-year fixed-term contracts, exclusivity clauses, conditions for unilateral termination), resulting in an incoherent hybrid regime. •⁠ ⁠Although classified as “employees,” professional athletes do not enjoy the social protection and retirement benefits normally afforded to workers. •⁠ ⁠As for amateur athletes, their status remains completely unaddressed by the law. The provisions aimed at supporting athlete training and post-career reconversion are equally deficient. They are neither mandatory nor widely implemented, few training centers exist, and many athletes lack the educational background needed to benefit from such programs. IV. The Need for a Moroccan Sports Code Faced with these structural weaknesses, a piecemeal revision of the law is no longer adequate. The codification of sports law—through the adoption of a comprehensive Moroccan Sports Code—is now an imperative step toward supporting the country’s international ambition. Drawing inspiration from the French model, such a reform would serve several key purposes: 1.⁠ ⁠Clarifying and consolidating the dispersed legal texts, regulations, and case law to facilitate specialization among legal practitioners. 2.⁠ ⁠Correcting inconsistencies by redefining the jurisdictional competences of the State and creating a sui generis legal status for professional and amateur athletes. 3.⁠ ⁠Modernizing the legal framework by integrating fiscal and social regimes specific to sports entities and individuals. Despite its initial promise of modernization, Law 30-09 has become a “tree with bitter fruits.” Instead of fostering professionalism, it has constrained the sector and amplified its institutional fragility. Only a complete codification—reflecting Morocco’s socio-economic realities and the principles of good governance—can ensure a coherent, autonomous, and sustainable framework for the country’s sports development.

Chapter 5: Synthesis- The Consilience of the Framework 374

Satta Abraham, 2 d.
The evidentiary power and utility of this integrated framework—Orbits, Latticework, Pipeline—lies in its consilience. It weaves breakthroughs from wildly disparate fields into a single, coherent explanatory tapestry, revealing a universal pattern of successful inquiry. From Ballpark to Trading Floor: The narratives of Moneyball and The Big Short are isomorphic: Both begin with a philosophical reframing of value (what makes a baseball player valuable; what is the true risk of a mortgage bond). Both proceed through scientific, data-driven discovery of a massive market inefficiency (OBP vs. price; real default risk vs. AAA ratings). Both culminate in the formulation and execution of a winning model (a roster of undervalued players; a portfolio of credit default swaps). They are the same story, told in different arenas. From Sideline to Boardroom- José Mourinho’s Tactical Objectivity: The strategic success of football manager José Mourinho, particularly in his early career at Porto, Chelsea, and Inter Milan, can be precisely deconstructed through this lens. Lacking a storied playing career, he was unburdened by the sport’s internal, dogmatic "ways of knowing." His Outer Orbit philosophy was defined with stark clarity: winning is the sole aesthetic. His Middle Orbit work became legendary: obsessive, scientific analysis of opponents, involving countless hours of video to identify specific tactical vulnerabilities in individual players and systemic gaps in team shape. His Inner Orbit genius was in formulation: he would design rigorous, often defensively-oriented game models tailored to exploit those precise weaknesses, demanding robotic discipline from his players. His famous 1-0 victories, frequently derided as "anti-football" or "boring," were direct, logical products of pursuing objective victory over subjective aesthetic approval. He demonstrated that objectivity often requires enduring backlash from a consensus invested in a different, more romantic model of the game. From Factory Flow to Protein Fold: Taiichi Ohno’s andon cord and Demis Hassabis’s AlphaFold: Both are profound interventions based on latticework understanding. Ohno designed a human-technological system to make local truth (a defect) instantly global, optimizing a physical manufacturing lattice. Hassabis built a computational system to infer the spatial relationship lattice of amino acids from evolutionary data, optimizing our understanding of the biological lattice. One is mechanical and human, the other digital and abstract, but both are solutions born from seeing a problem as a network of relationships to be modeled and managed. The Contemporary Imperative-The Age of the Synthesist: The historical drift of knowledge since the Enlightenment has been from integration toward fragmentation. The Renaissance ideal of the uomo universale (universal man) gave way to the Industrial Age’s demand for the hyper-specialist. The 20th century perfected the silo. The 21st century, however, presents us with a stark imperative that demands a synthesis, a return to integrated thinking, but now armed with powerful new tools and facing problems of unprecedented scale. Two convergent forces make the orbital, latticework methodology not merely beneficial, but essential for competent navigation of our time. The Nature of Our Tools: Our most powerful analytical engines—Artificial Intelligence (particularly machine learning and large language models) and, on the horizon, Quantum Computing—are inherently cross-orbital and lattice-native. Deploying AI effectively on any complex problem, from drug discovery to climate modeling to ethical dilemma resolution, requires precise philosophical framing (defining objectives, values, and constraints to avoid perverse outcomes), robust and curated scientific data grounding, and exquisite mathematical formulation of the model architecture and training paradigm. These tools fail, often catastrophically and insidiously, with fragmented, siloed, or philosophically unexamined input. They demand, and therefore will select for, synthesist thinkers who can navigate all three orbits and think in terms of interconnected systems. The Nature of Our Challenges: The existential problems that define our epoch are quintessential latticework challenges. They cannot be contained within academic departments or government agencies. They are not "physics problems" or "economics problems." They are system problems. The specialized intellect, trained to dig ever deeper into a single vertical silo, is architecturally unequipped to even properly define them, let alone solve them. These challenges demand minds capable of orbital thinking across the lattice, minds that can hold multiple models, trace second- and third-order consequences, and formulate strategies that are robust across multiple domains of reality. Objectivity as the Foundational Operating System. The pursuit of objective truth is not a passive state of receiving revealed wisdom. It is an active, disciplined, and often confrontational chase. It requires the moral courage to question foundational premises in the Outer Orbit, the intellectual rigor to map reality without favor or illusion in the Middle Orbit, and the creative potency to formally synthesize understanding in the Inner Orbit. It demands that we see the world not as a collection of unrelated events, but as a vast, dynamic lattice of interlocking causes and effects. And it is best navigated with the structured, self-correcting protocol of the Objectivity Pipeline. This framework proposes objectivity not as the cold, emotionless province of a narrow scientism, but as a universal operating system for understanding, a scalable, rigorous, and ultimately humane methodology applicable with equal force to the equations of a physicist, the ethical calculus of a jurist, the investment thesis of a historian, the innovation of an engineer, and the strategy of a state. Subjectivity is the fog of un-modeled complexity. The Orbits Model, the Latticework Theory, and the Objectivity Pipeline constitute the navigation system—the charts, the compass, and the piloting protocol. In an epoch defined by overwhelming information, pervasive misinformation, and tools of god-like power whose misuse carries existential risk, mastering this chase is no longer an intellectual luxury or a philosophical pastime. It is the essential meta-skill, the foundational logic upon which reliable judgment, effective action, and meaningful progress depend. The choice before us is not between a subjective world and an objective one, but between wandering in the fog and building a lighthouse. The architecture for the lighthouse is here. The materials are the disciplines of thought we have inherited and refined. The builders must now be us.